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ProteomicsProcess and Workflow for Preparation of Disparate Mouse Tissues for Proteomic Analysis
We investigated the effect of homogenization strategy and protein precipitation on downstream protein quantitation using multiple reaction monitoring mass spectrometry (MRM-MS). Our objective was to develop a workflow capable of processing disparate tissue types with high throughput, minimal variabi...
ORGANISM(S): Mus Musculus 
2021-01-24 | PXD019539 | panorama
TranscriptomicsRNA sequencing reveals two major classes of gene expression levels in metazoan cells
The expression level of a gene is often used as a proxy for determining whether the protein or RNA product is functional in a cell or tissue. Therefore, it is of fundamental importance to understand the global distribution of gene expression levels, and to be able to interpret it mechanistically and...
ORGANISM(S): Mus musculus 
2011-04-16 | E-GEOD-28666 | biostudies-arrayexpress
UnknownExpert consensus on treating HR+/HER2- metastatic breast cancer based on real-world practice patterns observed in the RETRACT survey of US oncologists.
Not available
S-EPMC12138406 | biostudies-literature
TranscriptomicsTranscription profiling of Neisseria meningitidis knock out mutant of snC transcriptional regulator compared to parent strains
Knock out mutant of asnC transcriptional regulator (NMB0573) in N. meningitidis MC58 compared to parent strains (capsule deletion mutant) grown in normal bacterial solid media plate conditions.
ORGANISM(S): Neisseria meningitidis 
2007-04-05 | E-MEXP-925 | biostudies-arrayexpress
UnknownPhase I study of sapanisertib (CB-228/TAK-228/MLN0128) in combination with ziv-aflibercept in patients with advanced solid tumors.
Not available
S-EPMC10891443 | biostudies-literature
TranscriptomicsA potential role for snoRNA in PKR activation during metabolic stress
PKR (Protein Kinase RNA-activated) is activated by metabolic stress, such as that associated with obesity, and this activation depends on its RNA-binding domain. Here we investigated whether endogenous RNA triggers PKR activation in response to lipid exposure. Our results indicate that snoRNAs (smal...
ORGANISM(S): Mus musculus 
2015-05-08 | E-GEOD-66540 | biostudies-arrayexpress
GenomicsPopulation Architecture using Genomics and Epidemiology (PAGE): Causal Variants Across the Life Course (CALiCo): Coronary Artery Risk Development in Young Adults (CARDIA)

CALiCo CARDIA
The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a study examining how heart disease develops in adults. It began in 1986 with a group of 5115 black and white men and women aged 18-30 years. The participants were selected so that there would be appr...

phs000236.v1.p1 | EGA
GenomicsPopulation Architecture using Genomics and Epidemiology (PAGE): Causal Variants Across the Life Course (CALiCo): Atherosclerosis Risk in Communities (ARIC)

CALiCo ARIC
The Atherosclerosis Risk in Communities Study (ARIC), sponsored by the National Heart, Lung and Blood Institute (NHLBI), is a prospective epidemiologic study conducted in four U.S. communities. ARIC is designed to investigate the etiology and natural history of atheroscler...

phs000223.v1.p1 | EGA
TranscriptomicsJarid2 regulates hematopoietic stem cell function by acting with Polycomb Repressive Complex 2
Polycomb Repressive Complex 2 (PRC2) has been shown to play a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is target...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-60808 | biostudies-arrayexpress
GenomicsPopulation Architecture using Genomics and Epidemiology (PAGE)

By relating hundreds of thousands of genotypes to only a few phenotypes, mostly in individuals of one ancestry, genome-wide association (GWA) studies are identifying a rapidly growing number of associations. The Population Architecture using Genomics and Epidemiology (PAGE) Study is designed to f...

phs000356.v1.p1 | EGA
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