Bet - OmicsDI

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Unknown (5164)
Genomics (1623)
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Organisms

Homo sapiens (855)
Mus musculus (577)
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human gammaherpesvirus 4 (8)
Caenorhabditis elegans (7)
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synthetic construct (4)
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Organisms

Homo sapiens (619)
Mus musculus (379)
Saccharomyces cerevisiae (11)
Schizosaccharomyces pombe (5)
Rattus norvegicus (5)
Drosophila melanogaster (3)
Bacillus subtilis (3)
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Bacteria (1)
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Gallus gallus (1)
synthetic construct (1)
Cucumis sativus (1)

Repository

ENA (1236)
geo (1074)
biostudies-arrayexpress (420)
pride (52)
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Tissue

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Schizophrenia (1)
Substance abuse (1)
Systemic lupus erythematosus (1)
Ulcerative colitis (1)

Technology Type

Mass Spectrometry (52)
Shotgun proteomics (28)
Bottom-up proteomics (11)
NMR spectroscopy (9)
Mass spectrometry (6)
SWATH MS (6)
Mass spectrometry assay (5)
Affinity purification coupled with mass spectrometry proteomics (5)
Data-dependent acquisition (4)
Data-independent acquisition (2)
Gel-based experiment (2)
Illumina_Infinium_HumanMethylation450, Illumina_HumanHT-12v4 (1)
Illumina HiSeq 2500 (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)

Instrument Platform

NextSeq 500 (18)
Illumina NovaSeq 6000 (17)
Illumina HiSeq 2500 (11)
Illumina HiSeq 4000 (8)
NextSeq 550 (5)
TripleTOF 5600 (5)
Q Exactive (4)
NextSeq 2000 (3)
MinION (2)
Illumina HiSeq 2000 (2)
Q Exactive Plus (2)
BD Influx Cell Sorter (1)
I.DOT (Dispendix), C.WASH (CYTENA), Qubit Fluorometer (Thermo Fisher Scientific), Agilent TapeStation 4200 (1)
BD FACSDiscover S8 (1)
QuantSeq 3’ mRNA-Seq Library Prep Kit FWD (Lexogen Gmbh, Vienna, Austria) (1)
MoFlo XDP (Beckman Coulter) or a FACSAria II (Becton Dickinson) (1)
Fluidigm C1 autoprep system (1)
Gene Titan (1)
Illumina Genome Analyzer IIx (1)
Sony SH800S (1)
TruSeq (Illumina, Novogene, Genomic Centre Cambridge, CB4 0FW, UK.) (1)
NanoDrop spectrophotometer and the Agilent 2100 Bioanalyzer (1)
Histopaque-1077,FACSAria Fusion Sorter,Flow Cytometer (1)
DNBSEQ-G400 (1)
Illumina MiSeq (1)
Illumina HiSeq 3000 (1)
- (1)
6230A Time-of-Flight LC/MS (1)
6545 Q-TOF LC/MS (1)
Bruker Daltonics instrument model (1)

Publication Date

2022 (125)
2020 (124)
2026 (122)
2021 (117)
2013 (112)
2016 (108)
2025 (107)
2024 (103)
2023 (100)
2017 (99)
2015 (96)
2018 (82)
2019 (79)
2014 (66)
2012 (55)
2010 (38)
2011 (22)
2009 (17)
2008 (11)
2007 (9)
2006 (4)

UNIPROT ID/AC

A0A1S3MBI7 (1)
A0A1S3RDV7 (1)
A0A1S3SLA8 (1)
B5X3P0 (1)
A0A1S3N3T3 (1)
A0A1S3NZZ4 (1)
A0A1S3P094 (1)
A0A1S3PY93 (1)
Q19VI0 (1)
A0A1S3M1N8 (1)
A0A1S3NHN0 (1)
A0A1S3KZD6 (1)
A0A1S3SD21 (1)
A0A1S3LDQ3 (1)
A0A1S3P3J9 (1)
A0A1S3LD76 (1)
A0A1S3LEH9 (1)
A0A1S3MF70 (1)
A0A1S3MF67 (1)
A0A1S3MEX0 (1)
A0A1S3MEU5 (1)
A0A1S3RYH9 (1)
A0A1S3RYI5 (1)
A0A1S3P4C7 (1)
A0A1S3P297 (1)
A0A1S3P8N0 (1)
A0A1S3PB08 (1)
A0A1S3N1B9 (1)
C0HBN7 (1)
A0A1S3LIF1 (1)

CHEBI ID

CHEBI:13097 (1)
CHEBI:21278 (1)
CHEBI:63163 (1)
CHEBI:6209 (1)
CHEBI:44590 (1)
CHEBI:21260 (1)
CHEBI:44513 (1)
CHEBI:6206 (1)
CHEBI:44708 (1)
CHEBI:44466 (1)
CHEBI:13094 (1)
CHEBI:47822 (1)
CHEBI:60107 (1)
CHEBI:21486 (1)
CHEBI:60111 (1)
CHEBI:43088 (1)
CHEBI:47823 (1)
CHEBI:28538 (1)
CHEBI:47819 (1)
CHEBI:47821 (1)
CHEBI:21601 (1)
CHEBI:7203 (1)
CHEBI:77859 (1)
CHEBI:19473 (1)
CHEBI:11524 (1)
CHEBI:1021 (1)
CHEBI:12542 (1)
CHEBI:47984 (1)
CHEBI:1022 (1)
CHEBI:42925 (1)

Metabolite Name

Histidine (6)
Glycine (6)
Betaine (6)
Phenylalanine (6)
Leucine (5)
Choline (5)
Taurine (5)
Alanine (5)
Glutamine (5)
Creatinine (5)
Creatine (5)
L-Cystine (4)
Lysine (4)
Asparagine (4)
Isoleucine (4)
Citrate (4)
Adipic acid (4)
Pyruvate (4)
Uridine (4)
Tryptophan (4)
Inosine (4)
Hypoxanthine (4)
Ethanol (3)
Chlorogenic acid (3)
Acetic acid (3)
Valylphenylalanine (3)
Formate (3)
L-ornithine (3)
S-Adenosylmethionine (3)
Glutamate (3)

First Public Date

2021 (124)
2024 (119)
2020 (119)
2026 (117)
2022 (112)
2019 (103)
2025 (100)
2023 (100)
2017 (91)
2018 (71)
2014 (62)
2016 (56)
2015 (37)
2013 (25)

Modelling Approach

Logical model (2)
Ordinary differential equation model (2)
Constraint-based model (1)

Study status

Not yet recruiting (2)
Terminated (1)
Recruiting (1)

Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA (3)
Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX (3)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
Dept. of Molecular Biosciences, University of Texas at Austin, Texas 78712 USA (2)
Systems Biology Ireland, University College Dublin (2)
The Drug Discovery Lab, Mary S. Easton Center for Alzheimer’s Disease Research, Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA (2)
- Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil (1)
1 Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, PR China 2 Department of Microbiology and Immunology, Tongji University School of Medicine, Shanghai 200049, PR China 3 Clinical Translation Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China. (1)
BRIC-National Centre for Cell Science, Pune (1)
Beijing institute of Lifeomics (1)
Biozentrum, University of Basel, Basel, Switzerland (1)
Core Unit Proteomics, Berlin Institute of Health at Charite - Universitaetsmedizin Berlin and Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany (1)
Dana-Farber Cancer Institute 450 Brookline Avenue, Longwood Center 3217 Boston, MA 02215 (1)
Department of Biochemistry and Molecular Biology Medical University of South Carolina (1)
Department of Biochemistry, Vanderbilt University, USA (1)
Department of Cellular Biology and Immunology, Lab 201, IPBLN-CSIC, Granada, Spain. (1)
Department of Life Technologies and InFLAMES Research Flagship, University of Turku, FI-20014, Turku, Finland (1)
Department of Pathology, Boston Children's Hospital / Harvard Medical School (1)
Director, Proteomics and Metabolomics Facility, Center for Open Research Resources and Equipment, University of Connecticut, Storrs, CT, USA (1)
EDyP (1)
EDyP team (1)
Facutly of Science, University of Geneva (1)
Georgetown University, USA (1)
IRIC-Université de Montréal (1)
Institute for Biological Resources and Marine Biotechnologies (CNR), Italian National Research Council, Messina, Italy (1)
Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland (1)
Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany (1)
Leukemia Department, MD Anderson Cancer Center, Houston, TX 77030 (1)
Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Pharmacology, Laboratory of Pharmacology and Brain Biostructure, Smetna Str. 12, 31-343 Krakow, Poland (1)
Medicinal Chemistry, Monash Institute of Pharmaceutica Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia (1)

Keyword

INCB057643 (1)
Azacitidine (1)
Pembrolizumab (1)
Antineoplastic Agents, Immunological (1)
Antibodies (1)
Immunoglobulins (1)
Antibodies, Monoclonal (1)
CRC (1)
Capecitabine (1)
Cetuximab (1)

IsPrivate

False (5)

Classification

protozoa (2)
bacteria (1)

Modification

Not available (1)

Study type

Transcription profiling by array (178)
RNA-seq of coding RNA (69)
ChIP-seq (67)
ChIP-chip by tiling array (40)
RNA-seq of coding RNA from single cells (14)
Comparative genomic hybridization by array (6)
Unknown experiment type (5)
Transcription profiling by tiling array (5)
Other (5)
DNA-seq (5)
Methylation profiling by array (5)
Interventional (4)
Cell line - High-throughput sequencing (3)
Animal - Single-cell sequencing (2)
Animal - High-throughput sequencing (2)
ChIP-chip by array (2)
ATAC-seq (2)
Methylation profiling by high throughput sequencing (2)
RNA-seq of total RNA (2)
Translation profiling (1)
Capture-C (1)
Bisulfite-seq (1)
Single nucleus RNA sequencing (1)
CUT&RUN (1)
RNA-seq of non coding RNA (1)

Release Date

2022 (598)
2021 (518)
2023 (517)
2025 (508)
2020 (478)
2019 (402)
2018 (395)
2024 (393)
2015 (287)
2017 (275)
2016 (272)
2014 (203)
2013 (191)
2012 (123)
2026 (91)
2010 (79)
2011 (75)
2009 (45)
2008 (33)
2007 (33)
2006 (26)
2005 (11)
2000 (8)
2002 (6)
2003 (5)
2004 (4)
2001 (2)
1999 (2)
1998 (2)

Location

United States (2)
China (1)
Spain (1)
United Kingdom (1)

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Streptococcus anginosus promotes hepatocellular carcinoma progression and BET inhibitor resistance by inducing BRD4 lactylation

Hepatocellular carcinoma (HCC) is a highly aggressive form of carcinoma with a poor prognosis. Diagnostic markers and potential therapeutic targets for HCC are urgently needed. Here, we demonstrate that fecal microbiota transplantation (FMT) using stool samples from HCC patients significantly pro...

2025-12-05 | MTBLS12398 | MetaboLights

Genome wide expression analysis of BET inhibitor resistance

Bromodomain and Extra Terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a new therapeutic paradigm by directly targeting epigenetic readers. Early clinical trials have shown significant promise especially in acute myeloid leukaemia (AML)3; therefore the evaluation ...

ORGANISM(S): Mus musculus

2015-09-15 | E-GEOD-63575 | biostudies-arrayexpress

Therapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer (ChIP-Seq)

Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. The development and progression to CRPC following androgen ablation therapy is predominantly driven by unregulated androgen receptor (AR) signaling1-3. Despite the success of recently approved...

ORGANISM(S): Homo sapiens

2014-04-25 | E-GEOD-55062 | biostudies-arrayexpress

ChIP of BET proteins in iBET resistance [ChIP-seq]

Bromodomain and Extra Terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a new therapeutic paradigm by directly targeting epigenetic readers1,2. Early clinical trials have shown significant promise especially in acute myeloid leukaemia (AML)3; therefore the evaluati...

ORGANISM(S): Mus musculus

2015-09-15 | E-GEOD-63682 | biostudies-arrayexpress

Genome-wide regulatory analysis reveals T-bet controls Th17 lineage differentiation through direct suppression of IRF4

The complex relationship between Th1 and Th17 cells is incompletely understood. The transcription factor T-bet is best known as the master regulator of Th1 lineage commitment. However, attention is now focused on the repression of alternate T cell subsets mediated by T-bet, particularly the Th17 lin...

ORGANISM(S): Mus musculus

2013-12-03 | E-GEOD-40623 | biostudies-arrayexpress

Genome wide expression analysis of BET inhibitor resistance [RNA-seq]

Bromodomain and Extra Terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a new therapeutic paradigm by directly targeting epigenetic readers1,2. Early clinical trials have shown significant promise especially in acute myeloid leukaemia (AML)3; therefore the evaluati...

ORGANISM(S): Mus musculus

2015-09-15 | E-GEOD-63681 | biostudies-arrayexpress

Functions of BET proteins in GATA1-mediated transcription [ChIP-seq]

Transcription factor GATA1 binding in erythroblasts in the presence and absence of BET inhibitor JQ1, and BET protein BRD3 and BRD4 binding in erythroblasts in the presence and absence of GATA1. Inhibitors of Bromodomain and Extra-Terminal motif proteins (BETs) are being evaluated for the treatment...

ORGANISM(S): Mus musculus

2015-02-23 | E-GEOD-62736 | biostudies-arrayexpress

Functions of BET proteins in GATA1-mediated transcription [expression array]

Role of bromodomain and extra-terminal motif (BET) proteins in GATA1-null erythrolbasts (G1E) and in differentiation induced by activation of conditional GATA1 tested by addition of BET inhibitor JQ1 (250nM) Array protocols were conducted as described in the Ambion WT Expression Manual and the Affym...

ORGANISM(S): Mus musculus

2015-02-23 | E-GEOD-62709 | biostudies-arrayexpress

T-bet-depended but IFN-gamma-independent genes in GVHD

Given T-bet is a master regulator for Th1 differentiation that produce IFN-gamma, underlining mechanisms accounted for the distinct GVHD outcomes caused by T-bet- versus IFN-gamma-deficient donor T cells are unclear. We hypothesize that GVHD is regulated by T-bet-dependent but IFN-gamma-independe...

ORGANISM(S): Mus musculus

2014-10-30 | E-MTAB-2198 | biostudies-arrayexpress

Response and resistance to BET bromodomain inhibitors in triple negative breast cancer [ChIP-Seq]

Triple negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy. Here we report the preferential and high sensitivity of TNBCs to BET bromodomain inhibitors such as JQ1 manifested by cell cycle arrest in early G1, apoptosis, and induct...

ORGANISM(S): Homo sapiens

2016-01-07 | E-GEOD-63581 | biostudies-arrayexpress

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