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MetabolomicsAdipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma by stabilizing IRF4 via NAT10-mediated acetylation

Multiple myeloma (MM) remains an incurable hematologic malignancy despite advances in treatment. While obesity is a well-established risk factor, the underlying metabolic mechanisms by which adipocytes contribute to disease progression remain elusive. Here, we uncover a critical m...

2026-05-07 | MTBLS14445 | MetaboLights
Metabolomicsβ-Hydroxybutyrate Restores Social Deficits via Suppressing HDAC9 in the Anterior Cingulate Cortex of Shank3B-Deficient Mice

Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, yet effective interventions remain limited. Ketogenic diet (KD) shows behavioral benefits in ASD, but the underlying mechanisms remain unclear. Here, using Shank3B knockout (KO) mice, we find that KD induces syst...

2026-07-08 | MTBLS14381 | MetaboLights
MetabolomicsGPR109a-AMPK Axis Mediates the Attenuation of Uric Acid-Induced M1 Macrophage Polarization by β-hydroxybutyrate from Lacticaseibacillus rhamnosus M2b

Hyperuricemia (HUA) is a metabolic disorder marked by increased blood uric acid (UA) levels, closely linked to conditions such as gout. UA-induced macrophage M1 polarization fundamentally exacerbates inflammatory pathophysiology, but current HUA-specific immunoregulatory treatments are inadequat...

2026-01-26 | MTBLS13224 | MetaboLights
ProteomicsTargeting mitochondria-inflammation circuit by β-hydroxybutyrate mitigates heart failure with preserved ejection fraction
Rationale: Over 50% of heart failure patients have preserved, rather than reduced ejection fraction (HFpEF vs. HFrEF). Complexity of its pathophysiology and the lack of animal models hamper the development of effective therapy for HFpEF. Objective: This study was designed to investigate the metabol...
ORGANISM(S): Mus Musculus 
2021-10-22 | PXD021957 |
ClinicalPreliminary Investigation of β-hydroxybutyrate Supplementation in Colorectal Cancer Prevention
The aim of this study is to assess the feasibility of beta-hydroxybutyrate (BHB) supplementation in individuals who are undergoing a standard-of-care colonoscopy or flexible sigmoidoscopy.
2719536 | ecrin-mdr-crc
GenomicsHistone β-hydroxybutyrylation underlies the reno-protective effect of β-hydroxybutyrate in hypertensive Dahl Salt-Sensitive Rats [ATAC-seq]
Histone β-hydroxybutyrylation underlies the reno-protective effect of β-hydroxybutyrate in hypertensive Dahl Salt-Sensitive Rats [ATAC-seq]
PRJNA1269476 | ENA
GenomicsHistone β-hydroxybutyrylation underlies the reno-protective effect of β-hydroxybutyrate in hypertensive Dahl Salt-Sensitive Rats [RNA-seq]
Histone β-hydroxybutyrylation underlies the reno-protective effect of β-hydroxybutyrate in hypertensive Dahl Salt-Sensitive Rats [RNA-seq]
PRJNA1269477 | ENA
GenomicsBeta-hydroxybutyrate enhances mitochondrial energy metabolism through histone beta-hydroxybutyrylation
Beta-hydroxybutyrate (BHB) regulates gene expression through modulation of post-translational histone modifications, including histone beta-hydroxybutyrylation. In human renal tubular epithelial cells challenged with hydrogen peroxide, pretreatment with sodium beta-hydroxybutyrate (BHBNa) significan...
ORGANISM(S): Homo sapiens 
2026-05-09 | GSE329902 | GEO
GenomicsHistone β-hydroxybutyrylation underlies the reno-protective effect of β-hydroxybutyrate in hypertensive Dahl Salt-Sensitive Rats [ATAC-seq]
Background: Previously, we demonstrated that the ketone body, β-hydroxybutyrate, is a potent antihypertensive and reno-protective metabolite in Dahl Salt-Sensitive rats. However, the mechanism by which β-hydroxybutyrate confers these beneficial effects is understudied. Here we focused on determining...
ORGANISM(S): Rattus norvegicus 
2025-06-06 | GSE298452 | GEO
TranscriptomicsHistone β-hydroxybutyrylation underlies the reno-protective effect of β-hydroxybutyrate in hypertensive Dahl Salt-Sensitive Rats [RNA-seq]
Background: Previously, we demonstrated that the ketone body, β-hydroxybutyrate, is a potent antihypertensive and reno-protective metabolite in Dahl Salt-Sensitive rats. However, the mechanism by which β-hydroxybutyrate confers these beneficial effects is understudied. Here we focused on determining...
ORGANISM(S): Rattus norvegicus 
2025-06-06 | GSE298451 | GEO
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