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TranscriptomicsCell type characterization of Boost and Boost+ mDA neuron protocol in vitro and in grafted in unilateral 6-hydroxydopamine (OHDA)-induced Parkinsonian rats
This work presents an optimized mDA neuron differentiation strategy that builds on the clinical grade (“Boost”) protocol but includes the addition of FGF18 and IWP2 treatment (“Boost+”) at the mDA neurogenesis stage. Both protocols were characterized by single-nucleus RNA-seq and compared in terms o...
ORGANISM(S): Homo sapiens 
2026-03-10 | E-MTAB-14729 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of allelic series of miR-17~92 mutant embryos.
We report the generation of an allelic series of miR-17~92 mutant mice, each carrying the targeted deletion of specific miRNA families encoded by the cluster. We integrate the phenotypic characterization of these strains with RNA-seq analysis showing the consequences of selective miRNA inactivation ...
ORGANISM(S): Mus musculus 
2015-02-02 | E-GEOD-63813 | biostudies-arrayexpress
TranscriptomicsComprehensive evaluation of differential gene expression analysis methods for RNA-seq data
A large number of computational methods have been recently developed for analyzing differential gene expression (DE) in RNA-seq data. We report on a comprehensive evaluation of the commonly used DE methods using the SEQC benchmark data set and data from ENCODE project. We evaluated a number of key f...
ORGANISM(S): Homo sapiens 
2013-08-20 | E-GEOD-49712 | biostudies-arrayexpress
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