Sort   by:  
 Page size 
ProteomicsEssential requirement for IER3IP1 in B cell development
In a forward genetic screen of mice with N-ethyl-N-nitrosourea (ENU)-induced mutations for aberrant immune function, we identified animals with low percentages of B220+ cells in the peripheral blood. The causative mutation was in Ier3ip1, encoding immediate early response 3 interacting protein 1 (IE...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-09 | MSV000091025 | MassIVE
ProteomicsMidnolin stimulates proteasome activity necessary for lymphopoiesis and B cell cancer growth
We identified the essential gene encoding midnolin in a genetic screen in which multiple Midn alleles caused reductions in peripheral B cells and T cell-independent antibody responses. Causation was confirmed in mice with targeted deletion of 4 of 6 MIDN protein isoforms. MIDN augmented proteasome a...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-14 | MSV000093397 | MassIVE
UnknownPhysical Interactions With Bacteria and Protozoan Parasites Establish the Scavenger Receptor SSC4D as a Broad-Spectrum Pattern Recognition Receptor.
Not available
S-EPMC8739261 | biostudies-literature
ProteomicsCalcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases
S11537: anti-FLAG beads incubated with mouse B cell extract S11538: FLAG-Pacs1 purified from 293T cells on anti-FLAG beads S11536: FLAG-Pacs1 purified from 293T cells on anti-FLAG beads incubated with mouse B cell extract.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-02-03 | MSV000086799 | MassIVE
MetabolomicsGNPS - Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases
S11537: anti-FLAG beads incubated with mouse B cell extract S11538: FLAG-Pacs1 purified from 293T cells on anti-FLAG beads S11536: FLAG-Pacs1 purified from 293T cells on anti-FLAG beads incubated with mouse B cell extract.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-02-03 | MSV000086799 | GNPS
TranscriptomicsTranscription profiling of mouse Kir6.1-deficient heart following LPS challenge
KATP opposes depolarization of cells in the heart, smooth muscle, and other tissues by permitting the efflux of potassium ions and this efflux is evidently required to prevent unopposed vasoconstriction and insufficiency of coronary artery blood flow triggered by one or more cytokines induced in res...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7605 | biostudies-arrayexpress
TranscriptomicsSystems analysis identifies an essential role for SHARPIN in macrophage TLR2 responses (Affymetrix)
Our systems analysis reported here demonstrates that TLR-responses in macrophages are markedly impaired by SHARPIN deficiency, and that SHARPIN controls expression of a subset of TLR2-induced, NF-kB and AP-1 dependent genes that overlaps with those affected by the hypomorphic panr2 mutation in NEMO....
ORGANISM(S): Mus musculus 
2011-08-30 | E-GEOD-29891 | biostudies-arrayexpress
TranscriptomicsSystems analysis identifies an essential role for SHARPIN in macrophage TLR2 responses (Agilent)
Our systems analysis reported here demonstrates that TLR-responses in macrophages are markedly impaired by SHARPIN deficiency, and that SHARPIN controls expression of a subset of TLR2-induced, NF-kB and AP-1 dependent genes that overlaps with those affected by the hypomorphic panr2 mutation in NEMO....
ORGANISM(S): Mus musculus 
2011-08-30 | E-GEOD-29888 | biostudies-arrayexpress
ProteomicsTrans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation
A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. The mechanisms underlying the maintenance and function of this intestinal barrier are not completely ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-12-12 | MSV000090883 | MassIVE
UnknownCalcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases
Not available
S-SCDT-EMBOJ-2020-104888 | biostudies-other
Sort   by:  
 Page size