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ProteomicsRed Blood Cells Serve as a Primary Glucose Sink to Improve Glucose Tolerance at Altitude
High altitude conditions improve glucose tolerance and reduce diabetes risk, but the physiological mechanism is not well-understood. Using mouse models, we found that hypoxia alone robustly improved glucose tolerance and that the effect persisted for weeks after returning to normal oxygen levels. PE...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD071719 | Pride
Red blood cells Cross-linking Hypoxia 
ProteomicsDeep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent S-Nitroso Transfer
Red blood cells (RBCs) are transcriptionally silent yet dynamically remodel metabolism in response to oxygen tension. Using ultra-pure human RBCs, we generated the deepest contamination-free proteome to date (3,775 proteins) and mapped the oxygen-dependent interactome. These datasets reveal an oxyge...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD072059 | Pride
Erythrocytes Hyponia Red blood cells Nitric oxide 
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