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TranscriptomicsEffective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate
We investigated the ability of HDAC inhibitors (HDACi) to target CML stem cells. Treatment with HDACi combined with IM effectively induced apoptosis in quiescent CML progenitors resistant to elimination by IM alone, and eliminated CML stem cells capable of engrafting immunodeficient mice. In vivo ad...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-20876 | biostudies-arrayexpress
TranscriptomicsAltered Hematopoietic Cell Gene Expression Precedes Development of Therapy-Related Myelodysplasia and Identifies Patients at Risk
Therapy-related myelodysplasia or acute myeloid leukemia (t-MDS/AML) is a lethal complication of cancer treatment. Although t-MDS/AML development is associated with known genotoxic exposures, its pathogenesis is not well understood and methods to predict risk of development of t-MDS/AML in individua...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-23025 | biostudies-arrayexpress
TranscriptomicsThe effect of IM and MSC treatment on gene expression in CML CD34+ cells
Tyrosine kinase inhibitors (TKI) are highly effective in treatment of chronic myeloid leukemia (CML) but do not eliminate leukemia stem cells (LSC), which remain a potential source of relapse. TKI treatment effectively inhibits BCR-ABL kinase activity in CML LSC, suggesting that additional kinase-in...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-43225 | biostudies-arrayexpress
TranscriptomicsRole of MPL expression in determining heterogeneity of leukemia-initiating capacity of chronic myelogenous leukemia stem cells
Using a CML mouse model, we identified differences in gene expression between leukemic compared with non-leukemic LTHSC, including increased expression of the thrombopoietin (THPO) receptor MPL. LTHSC expressing high levels of MPL showed enhanced JAK/STAT signaling and proliferation in response to T...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-76123 | biostudies-arrayexpress
UnknownHigh Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.
Not available
S-EPMC5455698 | biostudies-literature
UnknownPolypill with or without Aspirin in Persons without Cardiovascular Disease.
Not available
S-EPMC7116860 | biostudies-literature
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Not available
S-EPMC10364875 | biostudies-literature
UnknownValidation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.
Not available
S-EPMC8855527 | biostudies-literature
UnknownMachine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score.
Not available
S-EPMC8344569 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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