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TranscriptomicsBone Marrow Derived Mesenchymal Stem Cells Incorporate Into the Prostate During Regrowth
Transcriptional profiling of mouse prostate stromal cells knocked out for Tgfbr2 were compared to that of the Tgfbr2-flox control. Elevated chemokine expression in the prostate stroma of a castrate resistant mouse model, Tgfbr2-fspKO, prompted us to determine the role of bone marrow derived cell r...
ORGANISM(S): Mus musculus 
2010-06-16 | E-GEOD-22130 | biostudies-arrayexpress
TranscriptomicsCells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations
Prostate cancer-associated stroma (CAS) plays an active role in malignant transformation, tumor progression, and metastasis. Molecular analyses of CAS have demonstrated significant changes in gene expression; however, conflicting evidence exists on whether genomic alterations in benign cells compris...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-76456 | biostudies-arrayexpress
TranscriptomicsThe E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity
Analysis of gene expression altered upon knockdown of Siah2 in prosate cancer cells. The objective is to elucidate which signaling pathways or transcription factors are regulated by the E3 ubiquitin ligase Siah2 in human prostate cancer cells. CWR22Rv1 cells were in fected with pLKO.1 control or Sia...
ORGANISM(S): Homo sapiens 
2013-03-19 | E-GEOD-38851 | biostudies-arrayexpress
TranscriptomicsThe E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity cancer.
The androgen receptor (AR) plays a central role in the development of castration resistant prostate cancer (CRPC). Here, we demonstrate that the ubiquitin ligase Siah2 targets a select pool of NCOR1-bound, transcriptionally inactive AR for ubiquitination dependent degradation, thereby promoting the ...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-44319 | biostudies-arrayexpress
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