Sort   by:  
 Page size 
TranscriptomicsEffects of purine de novo synthesis knockdown on gene expression in Drosophila melanogaster S2 tissue culture cells
The effect of inhibiting expression of the ade2 gene by RNA interference in Drosophila S2 tissue culture cells was examined. S2 cells underwnt three different dsRNA treatments. Two were for non-overlapping sequences of ade2 transcripts and the third was for a non-specific Chlamydomonas reinhardtii ...
ORGANISM(S): Drosophila melanogaster 
2010-12-01 | E-GEOD-24123 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of mouse embryonic stem cells (mES) and hemogenic gastruloids with MNX1 overexpression
Bulk RNA sequencing of 3-dimensional gastruloid differentiation system initiated from mouse embryonic stem (ES) cells and biased towards hemato-endothelial cell production with overexpression of MNX1 by lentiviral vector transduction
ORGANISM(S): Mus musculus 
2022-10-10 | E-MTAB-12173 | biostudies-arrayexpress
TranscriptomicsExpression data from human colon cancer cell line HCT116 with NFX1-91 knockdown and control cells
NFX1-91, a novel E6 cellular downstream target, functions as a transcriptional regulator and is involved in repressing hTERT expression. Other functions and downstream targets regulated by NFX1-91 were not well understood. We used microarrays to determine gene expression deregulated when NFX1-91 wa...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-23674 | biostudies-arrayexpress
TranscriptomicsGene array analysis of embryonic vs adult hypothalamic NPY expressing cell lines
Microarrays were used to examine gene expression changes between two hypothalamic cell lines derived from adult and embryonic tissues. Both cell lines endogenously express the protein Npy (neuropeptide y) which is involved in feeding and reproductive processes. Results identify novel gene candidates...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-30467 | biostudies-arrayexpress
Transcriptomicsc-MET inhibitor inducing KSHV+ primary effusion lymphoma apoptosis
KSHV is a principal causative agent of primary effusion lymphoma (PEL). Despite this knowledge about the close relationship between HGF/c-MET network and solid tumors development, the role of HGF/c-MET in KSHV-related malignancies remains mostly unclear. We report that HGF/c-MET pathway is highly ac...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-70594 | biostudies-arrayexpress
TranscriptomicsGlutamine sensitivity analysis identifies the xCT antiporter as a common triple negative breast tumor therapeutic target.
A small number of tumor-derived cell lines have formed the mainstay of cancer therapeutic development, yielding drugs with impact typically measured as months to disease progression. To develop more effective breast cancer therapeutics, and more readily understand their potential clinical impact, w...
ORGANISM(S): Homo sapiens 
2013-11-22 | E-GEOD-48984 | biostudies-arrayexpress
TranscriptomicsLenalidomide and Pomalidomide inhibit Multiple Myeloma-induced osteoclast formation and RANKL/OPG ratio in myeloma microenvironment targeting the expression of adhesion molecules.
Multiple myeloma (MM)-induced osteoclast (OC) formation occurs in close contact with MM cell infiltration into the bone marrow (BM) due to the imbalance of the receptor activator of NF-kappa-B ligand (RANKL)/osteoprotegerin (OPG) ratio in favor of RANKL in the micorenvironment. Soluble factors inclu...
ORGANISM(S): Homo sapiens 
2013-04-13 | E-GEOD-37302 | biostudies-arrayexpress
TranscriptomicsSuppression of Lung Adenocarcinoma Progression by Nkx2-1
Despite the high prevalence and poor outcome of patients with metastatic lung cancer, the mechanisms of tumour progression and metastasis remain largely uncharacterized. We modelled human lung adenocarcinoma, which frequently harbours activating point mutations in KRAS1 and inactivation of the p53-p...
ORGANISM(S): Mus musculus 
2011-01-27 | E-GEOD-26874 | biostudies-arrayexpress
TranscriptomicsNuclear Factor I/B is an Oncogene in Small Cell Lung Cancer
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed only after it has metastasized to distant sites (Meuwissen and Berns 2005; Cooper and Spiro 2006). Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels (Forgacs ...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29533 | biostudies-arrayexpress
TranscriptomicsIL-33 activates tumor stroma to promote intestinal polyposis
Tumor epithelial cells develop within a microenvironment consisting of extracellular matrix, growth factors, and cytokines produced by non-epithelial stromal cells. In response to paracrine signals from tumor epithelia, stromal cells modify the microenvironment to promote tumor growth and metastasis...
ORGANISM(S): Homo sapiens 
2015-04-29 | E-GEOD-62518 | biostudies-arrayexpress
Sort   by:  
 Page size