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UnknownAssociation of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study.
Genetic association studies of SLC6A4 (SERT) and obsessive-compulsive disorder (OCD) have been equivocal. We genotyped 1241 individuals in 278 pedigrees from the OCD Collaborative Genetics Study for 13 single-nucleotide polymorphisms, for the linked polymorphic region (LPR) indel with molecular hapl...
S-EPMC6528171 | biostudies-literature
UnknownGenome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.
Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based a...
S-EPMC11071577 | biostudies-literature
UnknownGenome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.
Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based a...
S-EPMC12165847 | biostudies-literature
UnknownMapping the genetic landscape across 14 psychiatric disorders.
Psychiatric disorders display high levels of comorbidity and genetic overlap1,2, challenging current diagnostic boundaries. For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar disorder3, genomic methods have revealed that the m...
S-EPMC12779569 | biostudies-literature
UnknownAnalysis of shared heritability in common disorders of the brain.
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and ...
S-EPMC6097237 | biostudies-literature
UnknownGenomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of...
S-EPMC7077032 | biostudies-literature
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