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ProteomicsInteraction networks of Weibel-Palade body regulators syntaxin-3 and syntaxin binding protein 5 in endothelial cells
The endothelium stores the hemostatic protein Von Willebrand factor (VWF) in endothelial storage organelles called Weibel-Palade bodies (WPBs). During maturation, WPBs recruit a complex of Rab GTPases and effectors that associate with components of the SNARE machinery that control WPB exocytosis. Re...
ORGANISM(S): Homo sapiens (Human) 
2023-01-06 | PXD012809 | Pride
Weibel-palade body  snare protein  syntaxin  protein-protein interactions 
ProteomicsA CRISPR/Cas9 engineered Von Willebrand factor deficient endothelial cell model shows alternative trafficking of Weibel-Palade body proteins
Synthesis of the hemostatic protein Von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel-Palade bodies (WPBs). In the absence of VWF, angiogenic and inflammatory mediators that are co-stored in WPBs are subject to alternative trafficking routes. In Von Willebr...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD013857 | Pride
Von willebrand factor Endothelial cells Protein transport Gene knockout techniques Secretory vesicles 
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