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TranscriptomicsGenome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Novel Role in Autophagy
This SuperSeries is composed of the following subset Series: GSE28082: Examination of hepatic SREBP-2 binding using ChIP-Seq GSE28083: Expression data from CH/LE Mice Refer to individual Series
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-28084 | biostudies-arrayexpress
GenomicsExamination of hepatic SREBP-2 binding using ChIP-Seq
Sterol regulatory element binding proteins (SREBPs) are key transcriptional regulators of lipid metabolism. To define functional differences between the three mammalian SREBPs we are using genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-28082 | biostudies-arrayexpress
TranscriptomicsExpression data from CH/LE Mice
We are using genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with different dietary conditions that enrich for specific SREBPs. We show that hepatic SREBP-2 binds preferentially to two different gene-proximal motifs as well as SREBP-2 dire...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-28083 | biostudies-arrayexpress
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