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TranscriptomicsExpression from early pre-hematopoietic progenitors from mouse embryo
Hematopoietic Stem Cells (HSC) are originated during embryonic development from endothelial-like cells located in the ventral side of the dorsal aorta around day E10-12 of murine development. This region is called AGM for Aorta/Gonad/Mesonephros and refers to the tissues around the hemogenic aorta. ...
ORGANISM(S): Mus musculus 
2012-07-02 | E-GEOD-35395 | biostudies-arrayexpress
TranscriptomicsChIP-on-chip with anti-RBPj antibody from embryonic AGM E11.5
Hematopoietic Stem Cells (HSC) are originated during embryonic development from endothelial-like cells located in the ventral side of the dorsal aorta around day E10-12 of murine development. This region is called AGM for Aorta/Gonad/Mesonephros refering to the tissues around the hemogenic aorta. He...
ORGANISM(S): Mus musculus 
2014-10-22 | E-GEOD-52094 | biostudies-arrayexpress
TranscriptomicsGene expression from MCF7 breast cancer cells
Gene expression from MCF7 breast cancer cells at different times of TNFa incubation:pcs2 and 14-3-3 transduced cells Keywords: Expression Profiling by array We analyzed 2 arrays from each condition:MCF7-control tnf 0, MCF7-control tnf 20min, MCF-control tnf 90min, MCF7-14-3-3 tnf 0, MCF7-14-3-3 tnf...
ORGANISM(S): Homo sapiens 
2012-04-12 | E-GEOD-37139 | biostudies-arrayexpress
GenomicsIkBa associates with histone H2A in human keratinocytes
Here, we demonstrate that IkBa displays a predominant and unique nuclear localization in normal basal keratinocytes. This nuclear IkBa binds the chromatin through direct interaction of the ankyrin repeats with histone H2A and associates with the promoter and regulatory regions of several development...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-30082 | biostudies-arrayexpress
TranscriptomicsChromatin function of IkBa: ChIP-on-chip of IkBa
The Inhibitor of the NFkB, IkBa, is the main regulator of the NFkB pathway. Our data has demonstrated that there is an alternative function for IkBa in the chromatin that affects HOX and other developmental genes. Keywords: CHIP-chip Chip-on-chip analysis has demonstrated that IkBa associates to th...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-24011 | biostudies-arrayexpress
TranscriptomicsBRAF-induced tumorigenesis is IKKalpha dependent but NF?B independent
Tumor cells carrying KRAS mutations activate the NF-?B pathway by different mechanisms, which contribute to the acquisition of essential cancer properties. The BRAF kinase, a downstream mediator of KRAS, is also mutated in a subset of colorectal cancers (CRC), which predicts bad prognosis and therap...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-57979 | biostudies-arrayexpress
TranscriptomicsSingle cell analysis of gastruloid hemogenic development
Time-course analysis of cell type specification in a 3-dimensional gastruloid differentiation system initiated from mouse embryonic stem (ES) cells and biased towards hemato-endothelial cell production.
ORGANISM(S): Mus musculus 
2022-10-09 | E-MTAB-12148 | biostudies-arrayexpress
TranscriptomicsSingle cell analysis of MNX1 overexpression in hemogenic gastruloids
Analysis of MNX1 over expression in a 3-dimensional gastruloid differentiation system initiated from mouse embryonic stem (ES) cells and biased towards hemato-endothelial cell production.
ORGANISM(S): Mus musculus 
2022-10-10 | E-MTAB-12149 | biostudies-arrayexpress
Genomicsena-DATASET-Hospital Clinic Barcelona-21-07-2015-12:09:53:274-78 - samples
RNASeq sequencing. Each library was sequenced using TruSeq SBS Kit v3-HS, in paired-end mode with a read length of 2 × 76 bp. We generated more than 20 million paired-end reads for each sample in a fraction of a sequencing lane on HiSeq2000 (Illumina Inc.) following the manufacturer’s protoc...
EGAD00001001443 | EGA
TranscriptomicsThe Notch/Hes1 pathway sustains NF-M-NM-:B activation through CYLD repression in T cell leukemia
The NF-M-NM-:B pathway is a critical regulator of the immune system and has been implicated in cellular transformation and tumorigenesis. NF-M-NM-:B response is regulated by the activation state of the IM-NM-:B kinase (IKK) complex and triggered by a wide spectrum of stimuli. We previously reported ...
ORGANISM(S): Homo sapiens 
2011-05-07 | E-GEOD-20667 | biostudies-arrayexpress
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