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TranscriptomicsRapid reprogramming of primary human astrocytes into potent tumor initiating cells with defined genetic factors
Cancer stem cells play key roles in human malignancies. However, their cellular and molecular origins are still poorly understood. Here we report the successful generation of cancer stem cells from primary human astrocytes by use of defined genetic factors. Combined transduction of four factors —m...
ORGANISM(S): Homo sapiens 
2016-11-07 | E-MTAB-4771 | biostudies-arrayexpress
TranscriptomicsDNA methylation alteration and gene expression sigature in brainstem, thalamic, and supratentorial gliomas
Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect due to their proximity to eloquent brain structures. Here, we performed a comprehesive genomic and epigenomic study, using gene expression and methylation microarrays, to research on th diffe...
ORGANISM(S): Homo sapiens 
2014-05-27 | E-GEOD-50774 | biostudies-arrayexpress
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