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MetabolomicsGut microbiota-induced perturbations in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis
Emerging evidence has shown that microbiota dysbiosis and aberrant bile acids (BAs) profiles are correlated with disease progression. This study elucidates dysregulated BAs metabolism in psoriasis patients and imiquimod-treated female mice, coupled with increased expression of the farnesoid X recept...
2026-03-31 | MTBLS14191 | MetaboLights
MetabolomicsGallbladder microbial species and host bile acids biosynthesis linked to cholesterol gallstone comparing to pigment individuals

Gallstones are crystalline deposits in the gallbladder that are traditionally classified as cholesterol, pigment or mixed stones based on their composition. Microbiota and host metabolism variances among the different types of gallstones remain largely unclear. Here, the bile and gallstone microb...

2024-03-11 | MTBLS7736 | MetaboLights
MetabolomicsDietary germ oil-derived phytosterols ameliorate hyperlipidemia by suppressing bile salt hydrolase-producing gut microbiota to enrich taurohyodeoxycholic acid_Serum bile acids in individuals with dyslipidemia

Dyslipidemia is a major cardiovascular risk factor. While dietary phytosterols are known to lower cholesterol, the mechanisms involving the gut-liver axis are not fully understood. By integrating human clinical trials and mechanistic animal models, we demonstrate that phytosterols improve lipid p...

2026-03-17 | MTBLS13654 | MetaboLights
MetabolomicsGut microbiota-induced perturbations in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis
Emerging evidence has shown that microbiota dysbiosis and aberrant bile acids (BAs) profiles are correlated with disease progression. This study elucidates dysregulated BAs metabolism in psoriasis patients and imiquimod-treated female mice, coupled with increased expression of the farnesoid X recept...
2026-03-29 | MTBLS14183 | MetaboLights
MetabolomicsSADI-S and SG Surgeries Induce Distinct Bile Acid Profiles Linked to Improved Glucose Metabolism via Microbiota Interactions_feces

Introduction:

Bariatric surgery profoundly improves type 2 diabetes (T2D); however, the specific mechanisms linking distinct procedures to metabolic benefits through bile acid (BA) remodeling remain incompletely understood. This study investigates the differential effects of single-anastomo...

2025-09-16 | MTBLS12715 | MetaboLights
MetabolomicsThe bile acid metabolome in umbilical cord blood and meconium of healthy newborns: Distinct characteristics and implications (Meconium analysis)

OBJECTIVE: To characterize the bile acid (BA) metabolomic profile of umbilical cord blood (UCB) and meconium in healthy newborns.

METHODS: Fifteen healthy newborns, which born in the Obstetrics Department of the Affiliated Hospital of Southwest Medical Univ...

2024-11-28 | MTBLS10267 | MetaboLights
MetabolomicsIntegrative analysis of gut microbiota, bile acid pathways, and immune dysregulation in dyslipidemia models_Bile acid profile of rat fecal samples

This study aims to compare changes in bile acid profiles between fecal samples from rats fed a standard control diet and those fed a high-fat diet.

2025-10-04 | MTBLS13092 | MetaboLights
MetabolomicsSADI-S and SG Surgeries Induce Distinct Bile Acid Profiles Linked to Improved Glucose Metabolism via Microbiota Interactions_serum

Introduction:

Bariatric surgery profoundly improves type 2 diabetes (T2D); however, the specific mechanisms linking distinct procedures to metabolic benefits through bile acid (BA) remodeling remain incompletely understood. This study investigates the differential effects of single-anastomo...

2025-09-16 | MTBLS12716 | MetaboLights
MetabolomicsThe bile acid metabolome in umbilical cord blood and meconium of healthy newborns: Distinct characteristics and implications (Umbilical cord blood analysis)

OBJECTIVE: To characterize the bile acid (BA) metabolomic profile of umbilical cord blood (UCB) and meconium in healthy newborns.

METHODS: Fifteen healthy newborns, which born in the Obstetrics Department of the Affiliated Hospital of Southwest Medical Univ...

2024-11-28 | MTBLS10266 | MetaboLights
MetabolomicsBile acid is a significant host factor shaping the gut microbiome of diet induced obese mice (targeted bile acid analysis assay)

BACKGROUND: Intestinal bacteria are known to regulate the bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulating the expression of fibroblast growth factor 19 through intestinal nuclear farnesoid X receptor (FXR). On the other hand, BAs directly regula...

2017-11-23 | MTBLS547 | MetaboLights
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