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MetabolomicsIdentification of amniotic fluid metabolomic and placental transcriptomic changes associated with abnormal development of cloned pig fetuses
Piglets cloned by somatic cell nuclear transfer (SCNT) show a high incidence of malformations and a high death rate during the perinatal period. To investigate the underlying mechanisms for abnormal development of cloned pig fetuses, we compared body weight, amniotic fluid (AF) metabolome, and place...
2020-01-08 | MTBLS666 | MetaboLights
ProteomicsHuman Bile LC-MS/MS - One Sample, One Shot - Evaluation of sample preparation protocols for the mass spectrometric proteome analysis of human bile fluid without extensive fractionation
The proteome analysis of bile fluid represents a promising strategy to identify biomarker candidates for various diseases of the hepatobiliary system. However, to obtain substantive results in biomarker discovery studies large patient cohorts necessarily need to be analyzed. Consequently, this would...
ORGANISM(S): Homo sapiens (Human) 
2017-05-03 | PXD004476 | Pride
Method comparison Proteomics Hepatocellular carcinoma Bile fluid Biomarkers Cholangiocellular carcinoma 
ProteomicsHuman Bile LC-MS/MS
The proteome analysis of bile fluid represents a promising strategy to identify biomarker candidates for various diseases of the hepatobiliary system. However, to obtain substantive results in biomarker discovery studies large patient cohorts necessarily need to be analyzed. Consequently, this would...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082926 | MassIVE
MetabolomicsParabacteroides distasonis alleviates Clostridioides difficile infection by reshaping bile acid metabolism and the gut microbiota

The aim of this study was to establish a mouse model of Clostridioides difficile infection (CDI) and to investigate the effects of intervention with live Parabacteroides distasonis and its culture supernatant on the fecal bile acid pool using a targeted metabolomics approach. By...

2026-02-04 | MTBLS13831 | MetaboLights
TranscriptomicsTranscription profiling of Enterococcus faecalis V583 treated with SDS and bovine bile
The effects of bovine bile and SDS on transcriptional events were studied by means of genome wide microarrays in Enterococcus faecalis V583. Transcriptional profiles were obtained through time series experiments over periods of 120min for cells treated with bile and the combination of SDS and bile,...
ORGANISM(S): Enterococcus faecalis 
2007-08-01 | E-TABM-242 | biostudies-arrayexpress
TranscriptomicsLactobacillus reuteri ATCC 55730: Before vs after exposure to 0.5% bile.
Transcriptional profiling of Lactobacillus reuteri ATCC 55730 mid-log cultures before vs after exposure to 0.5% bovine bile (oxgall). Two sets of array experiments were performed. One set compared the expression profiles of L. reuteri ATCC 55730 cells before bile exposure vs cells that had been exp...
ORGANISM(S): Lactobacillus reuteri 
2010-05-26 | E-GEOD-10155 | biostudies-arrayexpress
TranscriptomicsRegulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
Decreased bile secretion in rodents by either ligation of the common bile duct or induction of cirrhosis causes changes in the small intestine, including bacterial overgrowth and translocation across the mucosal barrier. Oral administration of bile acids inhibits these effects. The genes regulated b...
ORGANISM(S): Mus musculus 
2012-09-12 | E-GEOD-40821 | biostudies-arrayexpress
TranscriptomicsVALIDATION STUDY TO VERIFY DIAGNOSTIC MARKERS FOR LUNG CANCER IN ENDOBRONCHIAL LINING FLUID
We investigated whether biomarker analysis in endobronchial epithelial lining fluid (ELF) collected by bronchoscopic microsampling may be useful for a definitive preoperative diagnosis. Therefore we compared ELF samples close to nodule and from the contralateral site from patients with malignant or ...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-27553 | biostudies-arrayexpress
ProteomicsBile Salts Enhance the Susceptibility of the Allergenic Lipid Transfer Protein from Peach, Pru p 3 to in vitro gastrointestinal digestion
Sensitisation to the lipid transfer protein Pru p 3 is associated with severe allergic reactions to peach, the proteins stability being thought to play a role in its allergenicity. Lipid binding increases susceptibility of Pru p 3 to digestion and so the impact of bile salts on the in vitro gastroin...
ORGANISM(S): Prunus persica 
2023-10-24 | PXD037801 | Pride
Disulphide bonds Immunoactivity Digestibility Bile salts Pru p 3 
ProteomicsMulti-omics analysis of intestinal lavage fluid obtained from patients with liver disease
Metagenomics and metaproteomics analysis of intestinal lavage fluid sample obtained from healthy individuals and patients with liver disease during colonoscopy.
ORGANISM(S): Homo Sapiens 
PXD043045 |
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