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GenomicsThe B cell identity factor Pax5 regulates distinct transcriptional programs in early and late B lymphopoiesis
Pax5 controls the identity and development of B cells by repressing lineage-inappropriate genes and activating B-cell-specific genes. Here, we used genome-wide approaches to identify Pax5 target genes in pro-B and mature B cells. In these cell types, Pax5 bound to 40% of the cis- regulatory elements...
ORGANISM(S): Mus musculus 
2012-06-14 | E-GEOD-38046 | biostudies-arrayexpress
GenomicsEssential role of EBF1 in B cell immunity by controlling the generation and function of distinct mature B cell types
The transcription factor EBF1 is essential for lineage specification in early B cell development. Here we demonstrate by conditional mutagenesis that EBF1 was required for B cell commitment, pro-B cell development and subsequent transition to pre-B cells. Later in B cell development, EBF1 was essent...
ORGANISM(S): Mus musculus 
2012-03-20 | E-GEOD-35857 | biostudies-arrayexpress
GenomicsEssential role of the transcription factors E2A and E2-2 in germinal center B cell and plasma cell development
E2A is an essential regulator of early B-cell development. Here we demonstrated that E2A together with E2-2 controlled germinal-center B-cell and plasma cell development. As shown by identification of regulated E2A,E2-2 targets in activated B-cells, these E-proteins directly activated genes with imp...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-77744 | biostudies-arrayexpress
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