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GenomicsSetDB1 Contributes to Repression of Genes Encoding Developmental Regulators and Maintenance of ES Cell State
Transcription factors that play key roles in regulating embryonic stem (ES) cell state have been identified, but the chromatin regulators that help maintain ES cells are less well understood. A high-throughput shRNA screen was used to identify novel chromatin regulators that influence ES cell state...
ORGANISM(S): Mus musculus 
2009-11-01 | E-GEOD-18371 | biostudies-arrayexpress
GenomicsThe histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
The most common mutation in human melanoma, BRAF(V600E), activates the serine/threonine kinase BRAF and causes excessive activity in the mitogen-activated protein kinase pathway. BRAF(V600E) mutations are also present in benign melanocytic naevi, highlighting the importance of additional genetic alt...
ORGANISM(S): Homo sapiens 
2011-03-25 | E-GEOD-28170 | biostudies-arrayexpress
GenomicsControl of Embryonic Stem Cell State by Mediator and Cohesin (Illumina ChIP-Seq data)
The key transcription factors that control the embryonic stem cell gene expression program have been identified, but how they function to implement this program is not well understood. While screening for genes essential for maintenance of ES cell state, we identified many components of the Mediato...
ORGANISM(S): Mus musculus 
2010-08-12 | E-GEOD-22562 | biostudies-arrayexpress
GenomicsEnhancer Decommissioning by LSD1 During Embryonic Stem Cell Differentiation (ChIP-seq)
Transcription factors and chromatin modifiers play important roles in programming and reprogramming of cellular states during development. Much is known about the role of these regulators in gene activation, but relatively little is known about the critical process of enhancer silencing during diff...
ORGANISM(S): Mus musculus 
2012-01-03 | E-GEOD-27841 | biostudies-arrayexpress
TranscriptomicsControl of Embryonic Stem Cell State by Mediator and Cohesin (Agilent gene expression data)
The key transcription factors that control the embryonic stem cell gene expression program have been identified, but how they function to implement this program is not well understood. While screening for genes essential for maintenance of ES cell state, we identified many components of the Mediato...
ORGANISM(S): Mus musculus 
2010-08-12 | E-GEOD-22556 | biostudies-arrayexpress
GenomicsFOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells
The Mediator and Cohesin complexes control the cellular transcriptional program. However, it is not well understood how they are recruited to regulatory regions. Our study shows that the core transcriptional regulatory circuitry of cancer cells is essential to recruit Mediator, Cohesin and NIPBL to ...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-76893 | biostudies-arrayexpress
GenomicsChIP-Seq data for histone marks in estrogen-inducible MyoD1 fibroblasts
The conversion of fibroblasts to myotubes by forced expression of MyoD1 is among the earliest demonstrations of reprogramming of vertebrate cell state. To gain insights into the chromatin state of genes required for reprogramming, we profiled H3K4me3, H3K27me3 and H3K9me3. DNA was enriched by chro...
ORGANISM(S): Mus musculus 
2010-07-24 | E-GEOD-23078 | biostudies-arrayexpress
GenomicsChIP-Seq data in secondary fibroblast with dox-inducible cassettes for Oct4, Sox2 and Klf4.
The conversion of fibroblasts to induced pluripotent stem cells (iPS) by forced expression of Oct4, Sox2 and Klf4 is among the earliest demonstrations of reprogramming to a pluripotent state by forced expression of transcription factors. To gain insights into the transcriptional state of genes requi...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-24471 | biostudies-arrayexpress
GenomicsChIP-Seq data for histone marks in mouse embryonic fibroblasts
The conversion of mouse embryonic fibroblasts (MEFs) to induced pluripotent stem cells (iPS) by forced expression of Oct4, Sox2 and Klf4 is among the earliest demonstrations of reprogramming to a pluripotent state by forced expression of transcription factors. To gain insights into the chromatin sta...
ORGANISM(S): Mus musculus 
2011-01-19 | E-GEOD-26657 | biostudies-arrayexpress
GenomicsChIP-Seq for NIPBL for SMC1 in human lymphoblastoid cells (hLCLs)
The gene expression program is regulated by a cell-type specific chromosome architecture. The connection between enhancer and promoter regions is dependent on a protein complex containing Nipbl, Mediator and Cohesin. To gain insights into the chromosome architecture of human differentiated cells, we...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-GEOD-38395 | biostudies-arrayexpress
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