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TranscriptomicsCombinatorial role of two paralogous splicing factors, hnRNP L and L-like, in multiple-exon regulation of CD45 alternative splicing
The goal of this study was to investigate the role of hnRNP L-like in alternative pre-mRNA splicing in human B-cells through an RNA-Seq approach. RNA-Seq was performed in DG75 cell line with over expression of hnRNP L-like or GFP as control.
ORGANISM(S): Homo sapiens 
2012-03-28 | E-GEOD-33013 | biostudies-arrayexpress
TranscriptomicsExpression data from HeLa cells after hnRNP L knockdown (versus luciferase control), including cycloheximide treatment
Transient siRNA-mediated knockdown of hnRNP L, followed by cycloheximide treatment to eliminate NMD. Supplementary files GSE37561_activated_exon.txt and GSE37561_repressed_exon.txt list exons predicted to be activated and repressed by hnRNPL, respectively. 3 biological replicates of hnRNP L (lucife...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-37561 | biostudies-arrayexpress
TranscriptomicsGenomewide analysis of U1C-dependent alternative splicing
To investigate whether U1C plays a role in splicing regulation in human system, we performed siRNA-mediated knockdown of U1C in HeLa cells and analyzed alternative splicing patterns by high-throughput RNA sequencing (RNAseq) RNAseq performed with poly(A)+ selected total RNA from U1C-knockdown and co...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-42485 | biostudies-arrayexpress
TranscriptomicsIndividual-nucleotide resolution CLIP and high-throughput sequencing to map hnRNP L-RNA interactions in HeLa cells
Individual-nucleotide resolution UV-crosslinking and immunoprecipitation (iCLIP) combined with high-throughput sequencing was used to generate a transcriptome-wide binding map of hnRNP L. Supplementary file GSE37560_hnRNPL_crosslink_site.bed includes filtered crosslink sites of hnRNPL: combining da...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-37560 | biostudies-arrayexpress
TranscriptomicsNTRAS hnRNPL RNA sequencing in HUVECs
In the current project with aim to unequivocally characterize a novel splicing-regulatory network that proves to be a central mediator of endothelial barrier function and vascular integrity. At the core of this network is the endothelial enriched lncRNA NTRAS (annotated as RP11-354k1.1) is shown to ...
ORGANISM(S): Homo sapiens 
2022-01-10 | E-MTAB-11311 | biostudies-arrayexpress
UnknownThe splicing-regulatory lncRNA NTRAS sustains vascular integrity
Not available
S-SCDT-EMBOR-2021-54157-T | biostudies-other
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