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TranscriptomicsGlucocorticoid effect on mRNA translation in childhood acute lymphoblastic leukemia
Glucocorticoids (GCs) are a central component in treating childhood acute lymphoblastic leukemia (chALL). They mainly act via regulating gene transcription. However, control of mRNA translation by GC has never been assessed systematically. In our research, T- and precursor B-ALL cells were cultured ...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-48680 | biostudies-arrayexpress
TranscriptomicsLoss-of-function of MYO5B induces epithelial cell scattering in enterocytes
A non-functional myosin Vb motor in duodenal enterocytes results in disruption of epithelial cell polarity characterized by complete loss of microvilli and mislocalization of apical brush border proteins in the cytoplasm which finally cause a devastating disease in neonates with severe malabsorption...
ORGANISM(S): Homo sapiens 
2013-03-14 | E-GEOD-45134 | biostudies-arrayexpress
TranscriptomicsDifferential neuronal targeting of a new and 2 known calcium channel M-NM-24 subunit splice variants correlates with their regulation of gene expression
The M-NM-2 subunits of voltage-gated calcium channels regulate surface expression and gating of CaV1 and CaV2 M-NM-11 subunits, and thus contribute to neuronal excitability, neurotransmitter release and calcium-induced gene regulation. In addition certain M-NM-2 subunits are targeted into the nucleu...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-50822 | biostudies-arrayexpress
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