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MetabolomicsAntioxidant Activity, Phytochemical Profiling by UPLC-QTOF-MS, and In Silico Targeting of the RNA-Binding Protein DRBD18 of Trypanosoma brucei by Bioactive Compounds from Tetradenia riparia and Tetracera poggei
Oxidative stress plays a key role in the pathogenesis of African trypanosomiasis, and plant-derived antioxidants represent a promising source of dual-action compounds capable of both scavenging reactive oxygen species and interfering with parasite survival. The present study investigates the antioxi...
2026-09-10 | MTBLS15597 | MetaboLights
MetabolomicsComparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells

Introduction

Chronic inflammation is a hallmark of chronic wounds and inflammatory skin diseases. Due to a hyperactive and prolonged inflammation triggered by proinflammatory immune cells, transitioning to the repair and healing phase is halted. T cells may exacerbate the proinflammatory mil...
2025-07-09 | MTBLS9800 | MetaboLights
ProteomicsExploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1
Background. As current methods for antibiotic drug discovery are being outpaced by the rise of antimicrobial resistance, new methods and innovative technologies are necessary to replenish our dwindling arsenal of antimicrobial agents. To this end, we developed the PepSAVI-MS pipeline to expedite the...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2018-07-23 | PXD009003 | Pride
Peptidomics Antimicrobial peptides (amps) Bacterial secretome Mass spectrometry Enterococcus faecalis Bioactive peptides Natural products 
ProteomicsTMT-10plex-based phosphoproteomics of bioactive compounds in A549 cells
We conducted a comprehensive screening of bioactive compounds sourced from natural products, specifically targeting those capable of inducing apoptosis while inhibiting tyrosine kinase activity. Our investigation encompassed a diverse range of compounds, including pure compounds, compound mixtures, ...
ORGANISM(S): Homo sapiens (Human) 
2024-03-13 | PXD050555 | Pride
Post translational modification Lc-ms/ms Phosphorylation Apoptosis Lung epidermal cells Isobaric mass tag Egfr 
OtherDereplication of Natural Bioactive Products from Leaves of Stryphnodendron pulcherrimum
Stryphnodendron pulcherrimum is a species known to have a high content of tannins. Accordingly, its preparations are used in southern Para, Brazil, for their anti-inflammatory and antimicrobial activities, but so far, its chemical profile composition remains essentially unknown. We herein describe t...
ORGANISM(S): Stryphnodendron Pulcherrimum (ncbitaxon:397652) 
2021-12-14 | MSV000088562 | MassIVE
TranscriptomicsBioactive Pyridine-N-oxide Disulfides from Allium stipitatum
In this study, the researchers isolated a colorless waxy solid from the chloroform extract of Allium stipitatum as Compound 1. They demonstrated compound 1 is a potent bactericidal agent against nonreplicating Mycobacterium tuberculosis. Using microarray technology the authors report gene expression...
ORGANISM(S): Mycobacterium tuberculosis 
2009-08-15 | E-GEOD-17640 | biostudies-arrayexpress
GenomicsReplacement of nitrite in meat products by natural bioactive compounds results in reduced exposure to N-nitroso compounds: the PHYTOME project
Replacement of nitrite in meat products by natural bioactive compounds results in reduced exposure to N-nitroso compounds: the PHYTOME project
PRJNA622780 | ENA
UnknownGenome mining methods to discover bioactive natural products.
Not available
S-EPMC8597713 | biostudies-literature
UnknownBiochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds.
Not available
S-EPMC5135737 | biostudies-literature
UnknownNatural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus.
Not available
S-EPMC10062602 | biostudies-literature
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