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MetabolomicsEnvironmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach
Not available
ORGANISM(S): Homo sapiens 
ST001407 | MetabolomicsWorkbench
MetabolomicsA molecular index for biological age identified from the metabolome and senescence-associated secretome in humans.
Unlike chronological age, biological age is a strong indicator of health of an individual. However, the molecular fingerprint associated with biological age is ill-defined. To define a high-resolution signature of biological age, we analyzed metabolome, circulating senescence-associated secretome (S...
2024-01-24 | MTBLS1991 | MetaboLights
MetabolomicsCryogenic OrbiSIMS Localizes Semi-Volatile Molecules in Biological Tissues
OrbiSIMS is a recently developed instrument for label-free imaging of chemicals with micron spatial resolution and high mass resolution. We report a cryogenic workflow for OrbiSIMS (Cryo-OrbiSIMS) that improves chemical detection of lipids and other biomolecules in tissues. Cryo-OrbiSIMS boosts ioni...
2023-03-15 | MTBLS1873 | MetaboLights
MetabolomicsEnvironmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach (part-II)
Not available
ORGANISM(S): Homo sapiens 
ST001406 | MetabolomicsWorkbench
MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
MetabolomicsBiological Effects of Amphiphilic Copolymer Nanoparticle-Encapsulated Multi-target Chemotherapeutic Drugs on MCF-7 Human Breast Cancer Cells
INTRODUCTION: Amphiphilic copolymer nanoparticle-encapsulated multi-target chemotherapeutic drugs have attracted considerable attention due to their favorable drug efficiency and potential application prospect. Studies have shown that an amphiphilic copolymer, methoxypoly(ethylene glycol)-poly(lacti...
2018-05-03 | MTBLS430 | MetaboLights
MetabolomicsInteraction of Genetic Variants Activates Latent Metabolic Pathways in Yeast

Genetic interactions are fundamental to the architecture of complex traits, yet the molecular mechanisms by which variant combinations influence cellular pathways remain poorly understood. Here, we answer the question of whether interactions between genetic variants can activate unique pathways a...

2025-07-22 | MTBLS12761 | MetaboLights
MetabolomicsHepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease, however, recent advances support the notion that sepsis is accompanied by extensive metabolic ...

2020-01-10 | MTBLS1386 | MetaboLights
MetabolomicsExploratory metabolomic profiling in migraine with PFO: dysregulated pathways and potential biomarkers

Background: Emerging evidence implicates patent foramen ovale (PFO) as a potential contributor to migraine through paradoxical metabolite shunting, microembolism and hypoxemia. However, systematic characterization of metabolic alterations in migraine patients with PFO (PFO-M) remains un...

2026-03-26 | MTBLS13630 | MetaboLights
MetabolomicsMetabolomics Study of Serum and Urine Samples Reveals Metabolic Pathways and Biomarkers Associated with Pelvic Organ Prolapse
Pelvic organ prolapse (POP) is a common medical condition among women and involves complicated diagnostics and controversial surgical management. The exact molecular mechanism underlying POP is poorly understood, especially at the metabolism level. To explore the metabolic mechanism underlying POP a...
2019-08-14 | MTBLS1033 | MetaboLights
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