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TranscriptomicsAscites enriches for ovarian cancer stem-like cells that express membrane GRP78
Ovarian cancer patients are generally diagnosed at stage III/IV, when ascites is common. The volume of ascites positively correlates with the extent of metastasis and negatively with prognosis. Membrane GRP78, a stress-inducible endoplasmic reticulum chaperone which also appears on the plasma membra...
ORGANISM(S): Mus musculus 
2015-03-09 | E-GEOD-61285 | biostudies-arrayexpress
TranscriptomicsNew compounds triggering endoplasmic reticulum stress exert anti-melanoma effects and overcome BRAF inhibitor resistance
We discovered and developed a new series of molecules (thiazole benzenesulfonamides). HA15, the lead compound of this series, displayed anti-cancerous activity on all tested melanoma cells including those isolated from patients and those that developed resistance to BRAF inhibitors. Our molecule dis...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-79071 | biostudies-arrayexpress
UnknownHKH40A downregulates GRP78/BiP expression in cancer cells.
Not available
S-EPMC4047900 | biostudies-literature
UnknownGRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy.
Not available
S-EPMC8599848 | biostudies-literature
UnknownCab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP.
Not available
S-EPMC4047922 | biostudies-literature
UnknownARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responses.
Not available
S-EPMC11113179 | biostudies-literature
UnknownA novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis.
Not available
S-EPMC3328363 | biostudies-literature
ProteomicsCellular stress modulates severity of the inflammatory response in lungs via cell surface BiP
As BiP is involved in the ARDS mechanism of disease, we analyzed the proteomic profile of lung tissue challenged with LPS and/or treated with 4-PBA to identify pathways and components that link BiP and cellular stress with the hyperinflammatory response.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD037978 | Pride
Lps Inflammation Bip Covid19 Cellular stress Grp78 
UnknownThe Circulating GRP78/BiP Is a Marker of Metabolic Diseases and Atherosclerosis: Bringing Endoplasmic Reticulum Stress into the Clinical Scenario.
Not available
S-EPMC6912434 | biostudies-literature
UnknownData on the optimizations of expression and purification of human BiP/GRP78 protein in Escherichia coli.
Not available
S-EPMC5219641 | biostudies-literature
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