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MetabolomicsPseudomonas sp. Strain 273 Incorporates Organofluorine into the Lipid Bilayer during Growth with Fluorinated Alkanes
Anthropogenic organofluorine compounds are recalcitrant, globally distributed, and a human health concern. Although rare, natural processes synthesize fluorinated compounds, and some bacteria have evolved mechanisms to metabolize organofluorine compounds. Pseudomonas sp. strain 273 grows with...
2022-06-06 | MTBLS3893 | MetaboLights
TranscriptomicsIllumina microarray analysis of brain regions following acute exposure to bilirubin or LPS
We developed a novel mouse model of acute bilirubin toxicity. 450mg/kg bilirubin was administered IP to mice, which exhibited transient hearing deficits and ataxia at 4 hours, and recovered by 24 hours. This toxicity is consistent with the human symptoms of bilirubin toxicity. To investigate the mol...
ORGANISM(S): Mus musculus 
2018-08-26 | E-MTAB-7102 | biostudies-arrayexpress
TranscriptomicsA Wnt-Bmp feedback circuit controls inter-tissue signaling dynamics in tooth organogenesis
Gene expression profiling of the epithelial and mesenchymal compartments of the developing mouse tooth using Laser Capture Microdissected (LCM) or enzymatic treatment with Dispase to isolate the dental epithelial and mesenchymal tissue, over a developmental period from E10.0-E14.5. The data is also ...
ORGANISM(S): Mus musculus 
2012-01-13 | E-GEOD-32321 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of human fetal lung explants with R-SPONDIN Inhibition and human fetal lung primary tissue
Here, we used single cell RNA-sequencing (scRNA-seq) to profile 13-week post-conception distal human fetal lung explants cultured in an air liquid interface system and treated with an LGR5 ectodomain adenovirus that inhibits R-Spondin function or control adenovirus. A third, non-infected, condition ...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-10662 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of human fetal duodenal enteroids grown in EGF and/or NRG1
The purpose of this study was to interrogate the role of EGF-family ligands, in particular Epidermal Growth Factor (EGF) and Neuregulin 1 (NRG1), as human intestinal stem cell niche factors. An established duodenal enteroid line derived from a 20.2 week post conception biological specimen was expose...
ORGANISM(S): Homo sapiens 
2020-12-10 | E-MTAB-9720 | biostudies-arrayexpress
TranscriptomicsChromatin immunopreciptiation of human lymphoblastoid cells to identify histone H3K9/14 acetylation regions at common fragile sites
Map the histone H3K9/14 acetylation regions of in human cells at 7 common fragile sites and their flanking non-fragile sequences as well as a 200kb containing the rare fragile site FRAXA, a 1,075kb non-fragile region on chr22, a hyperacetylated region HALPHA44, and a heterochromatic region HET405. T...
ORGANISM(S): Homo sapiens 
2009-10-07 | E-TABM-347 | biostudies-arrayexpress
TranscriptomicsThe homeobox transcription factor Nkx2-1 regulates microRNAs controlling downstream gene silencing in lung epithelial cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-12-22 | E-GEOD-47055 | biostudies-arrayexpress
ProteomicsMechanisms of site-specific methylation by a highly conserved elongation factor 1A lysine methyltransferase
Translation elongation factor 1A (eEF1A) is an essential and highly conserved protein required for protein synthesis in eukaryotes. In both Saccharomyces cerevisiae and human, five different methyltransferase enzymes methylate specific residues on eEF1A, making eEF1A the eukaryotic protein targeted ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2024-01-03 | PXD042599 | Pride
Crosslinking mass spectrometry Protein methyltransferase Protein methylation 
TranscriptomicsRNA-seq of longitudinal human blood and nose swab samples from a controlled human infection experiment with SARS-CoV-2 virus
Controlled human infection experiments enable longitudinal profiling of immune responses to a pathogen. 36 healthy volunteers aged 18-29 years, with no evidence of previous infection or vaccination, were inoculated with SARS-CoV-2 virus and quarantined for 14 days. Blood samples for RNA sequencing w...
ORGANISM(S): Homo sapiens 
2024-04-08 | E-MTAB-12993 | biostudies-arrayexpress
GenomicsCHARGE
Aggregate results from a case-control study on stroke and ischemic stroke.
EGAD00000000029 | EGA
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