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MetabolomicsGut microbiota-mediated histidine deficiency drives testicular ferroptosis induced by bisphenol F exposure

Bisphenol F (BPF), a widespread environmental contaminant and a major substitute for the restricted bisphenol A (BPA), has raised increasing concerns regarding its potential male reproductive health risks, yet its underlying mechanisms remain poorly understood. This study investigates t...

2026-05-26 | MTBLS13997 | MetaboLights
MetabolomicsBisphenol mixture-induced DGKB downregulation promotes premature human neurogenesis through the activation of MAPK pathway

The widespread industrial transition from bisphenol A (BPA) to structural analogs such as BPS, BPE, and BPAF has raised significant concerns regarding their potential health risks. However, their neurodevelopmental risks and underlying molecular mechanisms, particularly when present as complex m...

2026-09-29 | MTBLS15671 | MetaboLights
TranscriptomicsGenistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of binding sites in a cell type-specific manner
To obtain an integrated view of gene regulation in response to environmental and endogenous estrogens on a genome-wide scale, we performed ChIP-seq, to identify estrogen receptor 1 (ER) binding sites, and RNA-seq in endometrial cancer cells exposed to bisphenol A (BPA; found in plastics), genistein ...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-38234 | biostudies-arrayexpress
TranscriptomicsEffects of low and high doses of bisphenol A on mouse liver transcriptome
Bisphenol A (BPA) is used in the plastic industry as the monomer of polycarbonates and epoxy resins. Heat and changes in pH conditions lead to its leakage from the plastics in which it is incorporated. This largely contributes to the widespread exposure of the general population to this environmenta...
ORGANISM(S): Mus musculus 
2011-09-20 | E-GEOD-26728 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of Human Endometrial Endothelial Cells Exposed to Bisphenol A
The endocrine disrupting chemical bisphenol A (BPA) can affect reproductive organs, tissues and cells in several species. Treatment of human endometrial endothelial cells (HEECs) with 50 µM BPA decreased their proliferation compared with the control. Microarray analyses revealed that BPA affected b...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-10802 | biostudies-arrayexpress
TranscriptomicsTranscriptome of human osteosarcoma (HOS) cells induced by bisphenol A, S and AF
Whole genome expression data on transcriptome of human osteosarcoma (HOS) cells induced by bisfenol A (BPA), S (BPAS) and AF (BPAF) after short- (8 hours) and long-term (3 months) exposure at human-relevant (10 nM) concentrations. 8 experimental conditions, 4x2 design: 3 compounds (bisphenol A, S an...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-50527 | biostudies-arrayexpress
TranscriptomicsGene expression change induced by bisphenol A in mouse urogenital sinus
Bisphenol A (BPA), an endocrine-disrupting chemical (EDC), is a well-known, ubiquitous estrogenic chemical. To investigate the effects of fetal exposure to low-dose BPA on the development of the prostate, we first examined the alterations of in situ sex steroid hormonal environment in the mouse urog...
ORGANISM(S): Mus musculus 
2010-12-06 | E-GEOD-24928 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice testicular sertoli cells from transgenic mice harboring a temperature-sensitive simian virus 40 large T-antigen a treated with bisphenol A to investigate the mechanisms by which bisphenol A (BPA) induces cell death
We performed global scale microarray analysis to identify detailed mechanisms by which bisphenol A (BPA) induce cell death by using an Affymetrix GeneChip system. Testicular Sertoli TTE3 cells used in the present study were derived from transgenic mice harboring a temperature-sensitive simian virus ...
ORGANISM(S): Mus musculus 
2007-11-24 | E-GEOD-4650 | biostudies-arrayexpress
TranscriptomicsEffects of bisphenol A on gene expression in adipocytes from lean children: association to metabolic disorders
Bisphenol A (BPA) is a xenobiotic endocrine disrupting chemical. In vitro and in vivo studies indicated that BPA alters endocrine-metabolic pathways in adipose tissue increasing the risk of developing metabolic disorders. BPA effects on human adipocytes, specifically in children, are poorly investig...
ORGANISM(S): Homo sapiens 
2015-07-09 | E-GEOD-58516 | biostudies-arrayexpress
TranscriptomicsmRNA -Seq of Danio rerio exposed to different concentrations of Bisphenol A against untreated control groups
In the present study transcriptome analysis was employed to investigate the early molecular responses to exposure to bisphenol A (CAS 80-05-7). Zebrafish embryos were exposed to to bisphenol A according to OECD guidelines (OECD test No. 236). At the end of exposure time (96 hours), simultaneous RNA...
ORGANISM(S): Danio rerio 
2024-11-25 | E-MTAB-14023 | biostudies-arrayexpress
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