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TranscriptomicsTranscription profiling of human mammary epithelial cell lines with finite life span and immortal non-malignant cells - time series
Nonmalignant human mammary epithelial cells (HMEC) seeded in laminin-rich extracellular matrix (lrECM) form polarized acini and, in doing so, transit from a disorganized proliferating state to an organized growth-arrested state. We hypothesized that the gene expression pattern of organized and growt...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-8096 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of finite life span and immortal non-malignant human mammary epithelial cell lines
We analyzed gene expression in 184 (finite life span) and HMT3522 S1 (immortal non-malignant) HMECs on successive days (3, 5, and 7) post-seeding in a laminin-rich extracellular matrix assay. Both HMECs underwent growth arrest in G0/G1 and differentiated into polarized acini between days 5 and 7.
ORGANISM(S): Homo sapiens 
2007-03-15 | E-MEXP-1006 | biostudies-arrayexpress
TranscriptomicsGene expression in organized and disorganized human breast epithelial cells
We have reported more than a dozen microenvironmental factors whose signaling must be integrated in order to effect an organized, functional tissue morphology. In order to identify underlying commonalities in gene transcription associated with the phenotype, we compared the gene expression of organi...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-50444 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF10A cells subjected to ionizing radiation and treatment with transforming growth factor beta-1.
Transforming growth factor beta-1 (TGFbeta) is a tumor suppressor during the initial stage of tumorigenesis, but it can switch to a tumor promoter during neoplastic progression. Ionizing radiation (IR), both a carcinogen and a therapeutic agent, induces TGFbeta activation in vivo. We now show that I...
ORGANISM(S): Homo sapiens 
2008-11-08 | E-GEOD-8240 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 25 breast cancer cell lines grown in 2D and 3D tissue culture conditions
A comparison of gene expression profiles for 25 breast cancer cell lines grown in 2D and 3D tissue culture conditions
ORGANISM(S): Homo sapiens 
2007-05-02 | E-TABM-244 | biostudies-arrayexpress
TranscriptomicsTumor exosome integrins determine organotropic metastasis
Stephen Paget first proposed, in 1889, that organ distribution of metastases is a non-random event, yet metastatic organotropism remains one of the greatest mysteries in cancer biology. Here, we demonstrate that exosomes released by lung-, liver- and brain-tropic tumor cells fuse preferentially with...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-68919 | biostudies-arrayexpress
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