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UnknownNrf2 functions as a biomarker and therapeutic target in lung cancer based on bibliometric analysis and molecular mechanisms.
Not available
S-EPMC12852516 | biostudies-literature
TranscriptomicsIdentification of Nrf2-regulated genes in A549 lung cancer cells by oligonucleotide microarray
To elucidate the mechanisms by which Nrf2 regulates cell growth, we performed global gene expression profiling of A549 lung cancer cells with knockdown of Nrf2. Gene networks associated with carbohydrate metabolism and drug metabolism were significantly downregulated in Nrf2-depleted A549 cells. Gen...
ORGANISM(S): Homo sapiens 
2013-07-04 | E-GEOD-38332 | biostudies-arrayexpress
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
TranscriptomicsTranscription profiling of mouse carotid bodies from A/J vs.DBA/2J
We hypothesize that gene expression in the CBs of these two strains of mice are divergent thus contributing to the disparity in the phenotypes. More specifically, (1) genes related to CB function are expressed less in the A/J mice compared to DBA/2J mice; (2) gene expression levels of morphogenic an...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5313 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cells transfected with MLV and HIV1 virus-like particles
We hypothesize that cellular mRNAs are incorporated nonselectively into retrovirus particles Experiment Overall Design: This study utilizes microarray analysis to test these hypotheses. Transfected cells were grown, RNA was isolated and used for global gene expression profiling (Affymetrix Human U13...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7213 | biostudies-arrayexpress
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