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TranscriptomicsGene Expression Patterns that Predict Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer Cell Lines and Human Lung Tumors
Global gene expression data were generated from cultured non small cell lung cancer cell lines (NSCLC), normalized using MAS 5.0, filtered and used to predict response of cells to EGFR inhibition Gene expression data from additional cell lines and tumors was used to validate the predictive algorithm...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-31625 | biostudies-arrayexpress
TranscriptomicsA phase II study of adding the multikinase sorafenib to existing endocrine therapy in patients with metastatic ER-positive breast cancer.
Growth factor signaling and angiogenesis may promote endocrine-resistance in breast cancer and blocking these pathways can overcome resistance in preclinical models. We conducted a phase-II study of adding the VEGFR/Ras/Raf/MAPK inhibitor sorafenib to endocrine therapy in metastatic ER-positive bre...
ORGANISM(S): Homo sapiens 
2012-09-13 | E-GEOD-40837 | biostudies-arrayexpress
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