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TranscriptomicsProstates of rats with induced partial bladder outlet obstruction and the effect of Eviprostat on those changes
Prostatic inflammation plays a role in the progression of benign prostatic hyperplasia (BPH). Eviprostat is an antiinflammatory and antioxidant phytotherapeutic agent widely used to treat lower urinary tract symptoms in BPH. However, because Eviprostat is a mixture of compounds from multiple natural...
ORGANISM(S): Rattus norvegicus 
2010-04-09 | E-GEOD-16063 | biostudies-arrayexpress
ProteomicsDe-obstruction of bladder outlet in humans reverses organ remodeling
Bladder outlet obstruction (BOO) causes lower urinary tract symptoms and objectifiable urodynamic changes in bladder function. We carried out an integrated transcriptome and proteome analysis of bladder samples from male patients with BOO before and 3 months after de-obstruction surgery (transurethr...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044777 | Pride
Remodelling Bladder Fibrosis Outlet obstruction 
ProteomicsFibroblast growth factor 2 promotes bladder hypertrophy caused by partial bladder outlet obstruction
The current study aims to investigate molecular alterations and biomarkers associated with partial BOO (PBOO) in rats.TMT-Labeling Proteomic Analysis of PBOO Bladder Tissues at Week 5.
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-10 | PXD024378 | Pride
Bladder outlet obstruction Rat Bladder hypertrophy 
TranscriptomicsLrig2 is required for maturation of peripheral nerves in the urinary bladder
Leucine-rich-repeats and immunoglobulin-like-domains (LRIG2) variants can occur in urofacial syndrome (UFS), an inherited disease characterised by functional bladder outlet obstruction. We aimed to define the pathobiology underlying UFS which we hypothesised would illuminate how the bladder becomes ...
ORGANISM(S): Mus musculus 
2020-04-27 | E-MTAB-6089 | biostudies-arrayexpress
ProteomicsRat-bladder-OAB - Proteomic analysis of urothelium of rats with detrusor overactivity induced by bladder outlet obstruction
Overactive bladder (OAB) syndrome is a condition that has four symptoms: urgency, urinary frequency, nocturia, and urge incontinence and negatively affects a patient’s life. Recently, it is considered that the urinary bladder urothelium is closely linked to pathogenesis of OAB. However, the mechanis...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-02-09 | PXD007571 | Pride
Oab Rat Bladder outlet obstruction Bladder 
Proteomicsrat bladder LC-MS/MS proteomics
Objective: Bladder outlet obstruction (BOO) is a common urologic disease associated with poorly understood molecular mechanisms. This study aimed to investigate the possible involvements of circRNAs (circular RNAs) and circRNA-encoded proteins in BOO development. Methods: The rat BOO model was esta...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-22 | PXD029337 | Pride
Rat Bladder Lc-ms/ms 
GenomicsFibroblast growth factor 2 promotes bladder hypertrophy caused by partial bladder outlet obstruction
Fibroblast growth factor 2 promotes bladder hypertrophy caused by partial bladder outlet obstruction
PRJNA704641 | ENA
GenomicsHuman - murine concordance of molecular signatures in nerve-sparing murine partial bladder outlet obstruction (NeMO)
Human - murine concordance of molecular signatures in nerve-sparing murine partial bladder outlet obstruction (NeMO)
PRJNA861847 | ENA
TranscriptomicsThe expression profile of circRNA, lncRNA and mRNA in the bladder tissue of partial bladder outlet obstruction rats before and after treatment of human urine-derived stem cells
Obstruction in any part between the outlet of the bladder and the external urethra is called partial Bladder outlet obstruction (pBOO), which is a common disease in urology, which may cause bladder dysfunction. We have comfirmed that human urine-derived stem cells (hUSCs) could improve the bladder f...
ORGANISM(S): Rattus norvegicus 
2021-04-02 | GSE171366 | GEO
GenomicsThe expression profile of miRNA in the bladder tissue of partial bladder outlet obstruction rats before and after treatment of human urine-derived stem cells
Obstruction in any part between the outlet of the bladder and the external urethra is called partial Bladder outlet obstruction (pBOO), which is a common disease in urology, which may cause bladder dysfunction. We have comfirmed that human urine-derived stem cells (hUSCs) could improve the bladder f...
ORGANISM(S): Rattus norvegicus 
2021-04-02 | GSE171293 | GEO
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