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UnknownCombining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer.
Not available
S-EPMC6242700 | biostudies-literature
ProteomicsConfirmation of cdk8/19 inhibitor selectivity and activity in colorectal cancer
The Mediator complex is an evolutionarily conserved regulator of gene expression, influencing chromatin structure and RNA polymerase II-mediated transcription. Its activity is modulated by a protein kinase module, which includes cyclin-dependent kinases 8 and 19, that phosphorylate RNA polymerase II...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD061476 | Pride
Inhibitor Cdk19 Phosphoproteome Cdk8 Colorectal cancer 
UnknownMapping the 3D structures of small molecule binding sites
Not available
S-EPMC5395517 | biostudies-literature
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [beta-catenin organoids]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Mus musculus 
2015-10-26 | E-GEOD-67847 | biostudies-arrayexpress
UnknownPlane of best fit: a novel method to characterize the three-dimensionality of molecules.
Not available
S-EPMC3477823 | biostudies-literature
UnknownScaffold diversity of exemplified medicinal chemistry space.
Not available
S-EPMC3180201 | biostudies-literature
UnknownTargeting Androgen Receptor Aberrations in Castration-Resistant Prostate Cancer.
Not available
S-EPMC5302169 | biostudies-literature
UnknownThe succinct synthesis of AT13387, a clinically relevant Hsp90 inhibitor.
Not available
S-EPMC7577423 | biostudies-literature
UnknownStructural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR).
Not available
S-EPMC2998101 | biostudies-literature
UnknownDiverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modification.
Not available
S-EPMC4122486 | biostudies-literature
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