Blair Sarah S - OmicsDI

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DNA methylation profiling in human Huntington's Disease brain

Despite extensive progress in Huntingtonâ??s Disease (HD) research, very little is known about the association of epigenetic variation and HD pathogenesis in human brain tissues. Moreover, its contribution to the tissue-specific transcriptional regulation of the huntingtin gene (HTT), in which HTT e...

ORGANISM(S): Homo sapiens

2016-03-11 | E-GEOD-79064 | biostudies-arrayexpress

Transcription profiling of striatal samples from 4 CHL2 Q150/Q150 mutant mice and 4 age-matched wild-type mice to investigate the study of huntingtin toxicity and its remedy in model systems.

Achieving a mechanistic understanding of disease and initiating preclinical therapeutic trials necessitate the study of huntingtin toxicity and its remedy in model systems. To allow the engagement of appropriate experimental paradigms, Huntingtonâ€™s disease (HD) models need to be validated in terms...

ORGANISM(S): Mus musculus

2008-04-10 | E-GEOD-10202 | biostudies-arrayexpress

Transcription profiling of mouse striatum from 3- and 18-month-old Q92 vs. control animals

ORGANISM(S): Mus musculus

2008-06-15 | E-GEOD-7958 | biostudies-arrayexpress

The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial.

Not available

S-EPMC5838871 | biostudies-literature

Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial.

Not available

S-EPMC6617509 | biostudies-literature

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial.