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TranscriptomicsRNAi knockdown of NMD in D Melanogaster
Two core factors of the NMD machinery in D. melanogaster, Upf1 and Upf2, were knocked down using RNAi, as described in Rehwinkel et al. (2005) RNA, PMID: 16199763. Each of the two knockdowns were compared to mock RNAi knockdowns as described in Blanchette et al. (2005) Genes Dev, PMID: 15937219 in a...
ORGANISM(S): Drosophila melanogaster 
2010-05-18 | E-GEOD-13532 | biostudies-arrayexpress
TranscriptomicsSplicing_Arrays_2
In this work, we have studied four closely related members of the five known Drosophila hnRNP A/B family, hrp36, hrp38, hrp40, and hrp48. Using splicing-sensitive microarrays, between 200 and 300 genes were detected as specifically regulated by each individual hrp protein following down regulation o...
ORGANISM(S): Drosophila melanogaster 
2008-12-30 | E-GEOD-13944 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human cell lines with oestrogen receptor (ER), the E2F transcription factor 4 (E2F4),
The Goal of the experiment was to validate the predicted regulatory modules identified by an algorithm.For this we took advantage of the the genome-wide location analysis technique (or ?ChIP/chip?). We selected modules predicted to be bound by the estrogen receptor (ER), the E2F transcription factor...
ORGANISM(S): Homo sapiens 
2006-05-01 | E-MEXP-471 | biostudies-arrayexpress
TranscriptomicsThe relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts [expression profiling]
Background: DNA methylation has long been known to play an essential role in the epigenetic regulation of gene expression and other cellular functions, and has been in some cases linked to genetic variation. While its presence near the transcription start site of a gene has been associated with red...
ORGANISM(S): Homo sapiens 
2013-12-13 | E-GEOD-53243 | biostudies-arrayexpress
GenomicsThe relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts [Whole genome bisulfite sequencing]
Background DNA methylation has long been known to play an essential role in the epigenetic regulation of gene expression and other cellular functions, and has been in some cases linked to genetic variation. While its presence near the transcription start site of a gene has been associated with reduc...
ORGANISM(S): Homo sapiens 
2014-01-25 | E-GEOD-54373 | biostudies-arrayexpress
TranscriptomicsA function for the hnRNP A1/A2 proteins in transcription elongation
The hnRNP A1 and A2 proteins regulate processes such as alternative pre-mRNA splicing and mRNA stability. Here, we report that a reduction in the levels of hnRNP A1 and A2 by RNA interference or their cytoplasmic retention by osmotic stress drastically increases the transcription of a reporter gene....
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-67617 | biostudies-arrayexpress
UnknownCD98hc is a target for brain delivery of biotherapeutics.
Not available
S-EPMC10439950 | biostudies-literature
UnknownAuthor Correction: CD98hc is a target for brain delivery of biotherapeutics.
Not available
S-EPMC10484993 | biostudies-literature
TranscriptomicsThe relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts [methylation profiling]
Background DNA methylation has long been known to play an essential role in the epigenetic regulation of gene expression and other cellular functions, and has been in some cases linked to genetic variation. While its presence near the transcription start site of a gene has been associated with red...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-52025 | biostudies-arrayexpress
UnknownFungal Planet description sheets: 400-468.
Not available
S-EPMC4988374 | biostudies-literature
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