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UnknownSupplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness.
Not available
S-EPMC5996612 | biostudies-literature
TranscriptomicsRibosome Profiling of mouse skin squamous tumours
Purpose: Ribosome profiling has revolutionized systems-based analysis and which produces a “global snapshot” of all the ribosomes translationally active in a cell at a particular moment. The goals of this study are to first apply ribosome profiling to in vivo samples for the first time and in pa...
ORGANISM(S): Mus musculus 
2016-06-16 | E-GEOD-72066 | biostudies-arrayexpress
TranscriptomicsIFNa activates dormant HSCs in vivo
Maintenance of the blood system is dependent on dormant haematopoietic stem cells (HSCs) with long-term self-renewal capacity. Upon injury these cells are induced to proliferate in order to quickly re-establish homeostasis. The signalling molecules promoting the exit of HSCs out of the dormant stage...
ORGANISM(S): Mus musculus 
2009-01-15 | E-GEOD-14361 | biostudies-arrayexpress
GenomicsLoss of cytosine-5 methylation in tRNA triggers stress responses in a disease model for Intellectual Disability
Mutations in the cytosine-5 RNA methyltransferase NSun2 can cause Intellectual Disability (ID) and symptoms commonly found in patients with Dubowitz syndrome. By analysing gene expression data with the global cytosine-5 RNA methylome in NSun2-deficient mice, we find that loss of cytosine-5 RNA met...
ORGANISM(S): Mus musculus 
2014-11-06 | E-GEOD-44746 | biostudies-arrayexpress
GenomicsTransfer RNA (tRNA) processing and RNA m5C-methylation profiles of mouse skin squamous tumours
Purpose: High-throughput RNA sequencing has accelerated discovery of the complex regulatory roles of small RNAs, such those derived from tRNAs. Also recent advances in high-throughput RNA sequencing has revealed the complex RNA modification landscape and the complex role these nucleosides modifactio...
ORGANISM(S): Mus musculus 
2016-06-16 | E-GEOD-72065 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling in skin of K14Sin3KO mice
Expression analysis of K14Sin3afl/flCreER,K14Mycfl/flCreER and K14Sin3aMycfl/flCreER effects on gene expression in adult mouse skin. We used a conditional knock out strategy to delete Sin3a and/or c-Myc specifically in adult mouse K14 positive keratinocytes and analysed the resulting changes in gene...
ORGANISM(S): Mus musculus 
2011-10-26 | E-MTAB-554 | biostudies-arrayexpress
TranscriptomicsGene expression analysis & Comparative genomic hybridization from Lung cancer Cell lines
Gene expression and Comparative genomic hybridization (CGH) microarrays performed in a set of 8 Lung cancer Cell lines. The search for oncogenes is becoming increasingly important in cancer genetics because they constitute suitable targets for therapeutic intervention. To identify novel oncogenes, a...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-14079 | biostudies-arrayexpress
UnknownTwo Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
Not available
S-EPMC10794000 | biostudies-literature
UnknownEvaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries.
Not available
S-EPMC10771257 | biostudies-literature
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