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TranscriptomicsFine-tuning of human dendritic cells regulation revealed by translational profiling
Dendritic cells (DCs) are the sentinels of the mammalian immune system and they undergo a complex maturation process mediated by activation upon pathogen detection. Recent studies described the analysis of activated DCs by transcriptional profiling, but translation regulation was never taken in acco...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-14000 | biostudies-arrayexpress
TranscriptomicsTrivalent Inactivated Influenza Vaccine (TIV) and Live Attenuated Influenza Vaccine (LAIV) Induce Different B cell and Transcriptional Responses in Children
LAIV and TIV are effective for prevention of influenza infection in children, but the mechanisms associated with protection are still not well defined. We analyzed the differences in B cell responses and transcriptional profiles. Compared to baseline, LAIV elicited a significant increase in naM-CM-/...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-52005 | biostudies-arrayexpress
TranscriptomicsInterferon Signature in the Blood in Inflammatory Common Variable Immune Deficiency [Test Set]
Transcriptional profiling was used to characterize the immunologic networks in subjects with CVID who have inflammatory complications to identify clues as to pathogenesis and potentially better modes of treatment. CVID subjects who fulfilled the standard diagnostic criteria, including significantly ...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-51404 | biostudies-arrayexpress
TranscriptomicsInterferon Signature in the Blood in Inflammatory Common Variable Immune Deficiency [Training Set]
Transcriptional profiling was used to characterize the immunologic networks in subjects with CVID who have inflammatory complications to identify clues as to pathogenesis and potentially better modes of treatment. CVID subjects who fulfilled the standard diagnostic criteria, including significantly ...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-51405 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human stemic juvenile idiopathic arthritis, , systemic lupus erythematosus,, type I diabetes, metastatic melanoma, acute infections, or liver-transplant recipients undergoing immunosuppressive therapy (n = 37)
The analysis of patient blood transcriptional profiles offers a means to investigate the immunological mechanisms relevant to human diseases on a genome-wide scale. In addition, such studies provide a basis for the discovery of clinically relevant biomarker signatures. We designed a strategy for mic...
ORGANISM(S): Homo sapiens 
2008-10-04 | E-GEOD-11907 | biostudies-arrayexpress
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