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TranscriptomicsExpression data in PD-L1 positive and PD-L1 negative human melanoma samples
Blocking the PD-1/PD-L1 immunosuppressive pathway has shown promise in the treatment of certain cancers including melanoma. This study investigates differences in the gene expression profiles of human melanomas that do or do not display the immunosuppressive protein PD-L1. Further understanding of g...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-65041 | biostudies-arrayexpress
TranscriptomicsHost gene expression signatures of influenza A H1N1 and H3N2 virus infection in adults
Diagnosis of influenza A infection is currently based on clinical symptoms and pathogen detection. Use of host peripheral blood gene expression data to classify individuals with influenza A virus infection represents a novel approach to infection diagnosis We used microarrays to assay peripheral bl...
ORGANISM(S): Homo sapiens 
2013-11-16 | E-GEOD-52428 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of zebrafish hearts treated with dioxin (TCDD)
For analysis of gene expression changes in the zebrafish larvae heart in response to TCDD exposure, three replicate samples of heart tissue were collected at 73, 74, 76 and 84 hours post fertilization from larvae exposed to 1 ng/ml TCDD or vehicle from 72 - 73 hours post fertilization. For analysis ...
ORGANISM(S): Danio rerio 
2006-06-29 | E-MEXP-758 | biostudies-arrayexpress
UnknownFilter exchange imaging with crusher gradient modelling detects increased blood-brain barrier water permeability in response to mild lung infection.
Not available
S-EPMC10071630 | biostudies-literature
TranscriptomicsTranscription profiling of 61 Salmonella enterica serovar Typhimurium isoltates to identify hotspots in genome variation and distinguish between different isolates from the same geographical region
A collection of 61 Salmonella enterica serovar Typhimurium (S. Typhimurium) of animal and human origin, matched as closely as possible by phage type, antimicrobial resistance pattern and place / time of isolation, and sourced from farms or hospitals in Scotland, were analysed by antimicrobial suscep...
ORGANISM(S): Salmonella enterica serotype Typhimurium 
2007-06-09 | E-SGRP-6 | biostudies-arrayexpress
ProteomicsWEHI991 drug target identification by DIA Solvent PISA
Here we demonstrate PfSTART1 engagement by WEHI991 in the P. falciparum proteome using organic solvent-based Proteome Integral Solubility Alteration (Solvent PISA) assay coupled with Data Independent Acquisition Mass Spectrometry (DIA-MS).
ORGANISM(S): Plasmodium (plasmodium) 
2024-05-01 | PXD048262 | JPOST Repository
Transcriptomicssingle cell RNAseq of memory B cells in the context of rituximab-treated ITP patients
Rituximab (RTX) is widely used as a first-line therapeutic strategy in B cell-mediated autoimmune diseases. However, a large proportion of patients either do not respond to the treatment or relapse during B cell reconstitution. Primary immune thrombocytopenia (ITP) is a prototypic B cell mediated au...
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-9955 | biostudies-arrayexpress
TranscriptomicsNon-invasive Analysis of the Airway Transcriptome Discriminates Clinical Phenotypes of Asthma
BACKGROUND: Evaluation of the airway transcriptome may reveal patterns of gene expression that are associated with clinical phenotypes of asthma. To define transcriptomic endotypes of asthma (TEA) we analyzed gene expression in induced sputum that correlate with phenotypes of disease. METHODS: Ge...
ORGANISM(S): Homo sapiens 
2014-04-07 | E-GEOD-56396 | biostudies-arrayexpress
TranscriptomicsCritical role for the DNA receptor AIM2 in stem-cell proliferation and cancer
Colorectal cancer is a leading cause of cancer-related deaths. Mutations in the innate immune receptor AIM2 are frequently identified in patients with colorectal cancer, but how AIM2 modulates colonic tumorigenesis is unknown. Here, we found that Aim2-deficient mice were hypersusceptible to colonic ...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-69436 | biostudies-arrayexpress
TranscriptomicsGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the hostM-bM-^@M-^Ys inflammatory response to the pathogen represents a potential tool to improve upon current diagno...
ORGANISM(S): Mus musculus 
2013-01-11 | E-GEOD-33341 | biostudies-arrayexpress
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