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TranscriptomicsInteractions among Polycomb domains are guided by chromosome architecture
Polycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the regulation of PcG target genes. Here, we adapted the Chromosome Conformation Capture on Chip (4C) assay to systematically map chromosomal in...
ORGANISM(S): Drosophila melanogaster 
2011-05-09 | E-GEOD-23166 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in wild type and In(3LR)sep larval brain tissue (Drosophila)
We performed a series of microarray expression profile experiments in central brain tissue from 3rd instar larvae, interrogating expression differences between wild type and In(3LR)sep strains. Since our 4C data (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE23166), demonstrated dramatic chan...
ORGANISM(S): Drosophila melanogaster 
2011-05-09 | E-GEOD-26693 | biostudies-arrayexpress
GenomicsGene expression profiling of Eed knockout and Ezh2 knockout small intestinal crypts [ChIP-seq]
Polycomb-mediated gene repression plays an important role in adult stem cell maintenance. Direct targets of the Polycomb repressive complex PRC2 in th intestinal epithelium were revealed by performing ChIP-sequencing on crypt samples isolated from wild type murine small intestines. The resulting lis...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81577 | biostudies-arrayexpress
TranscriptomicsMapping of Polycomb binding in Drosophila larval brain tissue using DamID
We made Polycomb (PC) and histone H3 lysine 27 trimethylation (H3K27me3) chromatin binding maps in central brain tissue from 3rd instar larvae, allowing us to make a direct comparison to our 4C data (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE23166). Our results demonstrate that our PC and...
ORGANISM(S): Drosophila melanogaster 
2011-12-31 | E-GEOD-23298 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Eed knockout and Ezh2 knockout small intestinal crypts [RNA-seq]
Polycomb-mediated gene repression plays an important role in adult stem cell maintenance. We knocked out (using the inducible AhCre-LoxP system) Polycomb genes Eed and Ezh2 in the intestine for 6 weeks, after which crypts - the small intestinal stem cell zone - were harvested and RNA sequenced. We f...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81576 | biostudies-arrayexpress
TranscriptomicsPolycomb chromatin domains in Drosophila
This SuperSeries is composed of the following subset Series: GSE23166: Interactions among Polycomb domains are guided by chromosome architecture GSE26693: Gene expression profiling in wild type and In(3LR)sep larval brain tissue (Drosophila) Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2011-01-31 | E-GEOD-26694 | biostudies-arrayexpress
TranscriptomicsMapping of H3K27me3 enrichment in Drosophila larval brain tissue using ChIP-chip
We made Polycomb (PC) and histone H3 lysine 27 trimethylation (H3K27me3) chromatin binding maps in central brain tissue from 3rd instar larvae, allowing us to make a direct comparison to our 4C data (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE23166). Our results demonstrate that our PC and...
ORGANISM(S): Drosophila melanogaster 
2011-12-31 | E-GEOD-23299 | biostudies-arrayexpress
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