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TranscriptomicsSingle-cell RNA-seq of human breast tumor samples with exhausted and non-exhausted immune environments
Fresh human breast tumor tissue was dissociated into single cells and viably frozen. Patient samples were annotated as having an ""exhausted"" or ""non-exhausted"" immune environment based on CyTOF characterization of T cell phenotypes (Wagner et al, Cell 2019). 14 samples (7 exhausted, 7 non-exhaus...
ORGANISM(S): Homo sapiens 
2023-08-25 | E-MTAB-10607 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of tumor associated macrophages and T cells in clear cell renal cell carcinoma
Tumor associated macrophages and T cells were characterized in a cohort of 73 ccRCC and 5 healthy donors using mass cytometry. Macrophage and T cell subsets of interest were identified and sorted directly from samples known to contain a high frequency of these subsets. CD8+ PD-1- T cells (n=6), exha...
ORGANISM(S): Homo sapiens 
2017-05-04 | E-MTAB-5640 | biostudies-arrayexpress
TranscriptomicsRNA-seq of two human mammary epithelial cell lines (HMLE and HMLE-Twist-ER) treated with 4-hydroxytamoxifen vs control
Immortalized non-cancerous human mammary epithelial cells (HMLE) were transfected to express the murine fusion protein Twist1-estrogen receptor(point mutation G525R) (HTER). Twist1-mediated gene expression is activated by stimulation with 4-hydroxytamoxifen for several days and induces an epithelial...
ORGANISM(S): Homo sapiens 
2021-03-24 | E-MTAB-9365 | biostudies-arrayexpress
ProteomicsPhospho-networks in Ovarian Cancer Cell Lines
Cancer cells acquire pathological phenotypes through accumulation of mutations that perturb signaling processes. While thousands of mutations have been identified, mostly by genome-wide sequencing, systematic interpretation of their role in cancer and impact on cellular information processing is pre...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080700 | MassIVE
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