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MetabolomicsPlasma non-targeted metabolome of high- and low-body-weight broilers

In large-scale poultry farming, broilers of the same breed share a common genetic background and identical management conditions, yet substantial individual variation in body weight persists. In this study, we identified distinct plasma proteomic profiles between high and low weight broilers, wit...

2025-06-10 | MTBLS12390 | MetaboLights
MetabolomicsDynamic utilization of low-molecular-weight organic substrates across a microbial growth rate gradient

AIM: Low-molecular-weight organic substances (LMWOSs) are at the nexus between micro-organisms, plant roots, detritus and the soil mineral matrix. The nominal oxidation state of carbon (NOSC) has been suggested as a potential parameter for modelling microbial uptake rates of LMWO...

2023-08-14 | MTBLS3558 | MetaboLights
MetabolomicsEarly postnatal metabolic profile in neonates with different birth weight status: A pilot study

INTRODUCTION: Restricted or enhanced intrauterine growth is associated with elevated risks of early and late metabolic problems in humans. Metabolomics based on amino acid and carnitine/acylcarnitine profile may have a role in fetal and early postnatal energy metabolism. In this ...

2021-04-28 | MTBLS2376 | MetaboLights
MetabolomicsGut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice
Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-f...
2022-04-01 | MTBLS4431 | MetaboLights
MetabolomicsAn alkaline-extracted low-molecular-weight heteroglucan from Ganoderma lucidum enhances immunity by modulating the gut microbiota

Ganoderma lucidum polysaccharides exhibit various biological activities, but conventional extraction is biased toward high-molecular-weight polymers. This study aimed to explore the structure and bioactivity of low-molecular-weight polysaccharides from Ganoderma lucidum...

2026-06-18 | MTBLS14649 | MetaboLights
TranscriptomicsHigh weight differences between donor and recipient affect early kidney graft function -a role for IL-6 signaling
The frequency of delayed function of kidney transplants varies greatly and is associated with the quality of graft, donor age, and the duration of cold ischemia time. Body weight differences between donor and recipient can affect primary graft function. The underlying mechanism is poorly understood....
ORGANISM(S): Rattus norvegicus 
2010-04-08 | E-GEOD-15813 | biostudies-arrayexpress
MetabolomicsIntegration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes
Alteration of various metabolites has been linked to type 2 diabetes (T2D) and insulin resistance. However, identifying significant associations between metabolites and tissue-specific phenotypes requires a multi-omics approach. In a cohort of 42 subjects with different levels of glucose tolerance (...
2020-01-06 | MTBLS1051 | MetaboLights
TranscriptomicsTranscription profiling of human adipose Tissue during Weight Loss
We investigated the regulation of adipose tissue (AT) gene expression during different phases of a dietary weight loss program and its relationship with insulin sensitivity. Obese women followed a weight reduction program composed of an energy restriction phase (ER) with a 4-week very-low-calorie di...
ORGANISM(S): Homo sapiens 
2009-05-16 | E-GEOD-11975 | biostudies-arrayexpress
TranscriptomicsThe effect of progressive weight loss on metabolic function
The purpose of this study was to evaluate the effect of progressive weight loss (5, 10, 15% weight loss) on metabolic function such as multi-organ insulin sensitivity and beta-cell function in obese people. We conducted microarray analysis to determine the effect of progressive weight loss on adipos...
ORGANISM(S): Homo sapiens 
2016-02-26 | E-GEOD-70529 | biostudies-arrayexpress
TranscriptomicsSubcutaneous adipose tissue (SAT) gene expression patterns between weight control and regaining weight subjects
Objective: This work aimed at identifying and characterizing differences in subcutaneous adipose tissue (SAT) gene expression patterns between subjects succeeding weight control against subjects regaining weight 6 months after a low calorie diet program. Methods: Weight-reduced obese subjects from 8...
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-19494 | biostudies-arrayexpress
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