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TranscriptomicsSynergistic, context-dependent and hierarchical functions of hematopoietic progenitor niche components.
Specialized niche environments specify and maintain stem and progenitor cells, but little is known about the identities and functional interactions of niche components in vivo. Here, we describe a modular system for the generation of artificial hematopoietic niches in the mouse embryo. A circumscrib...
ORGANISM(S): Mus musculus 
2012-08-24 | E-GEOD-33268 | biostudies-arrayexpress
TranscriptomicsSynthetic Lethal Interaction Between Oncogenic KRAS Dependency and Suppression of STK33 in Human Cancer Cells
Many human oncogenes are challenging therapeutic targets. An alternative to direct targeting of oncogenes is to perform â??synthetic lethalityâ?? screens for genes that are essential only in the context of specific cancer-causing mutations. We used high-throughput RNA interference (RNAi) to identify...
ORGANISM(S): Homo sapiens 
2009-06-24 | E-GEOD-15151 | biostudies-arrayexpress
ModelsSobotta2017 - IL-6-induced JAK1-STAT3-signaling
Here we present a mathematical model of IL-6-induced JAK1-STAT3 signaling that quantitatively links physiological IL-6 concentrations to the dynamics of IL-6-induced signal transduction and expression of target genes in hepatocytes. The mathematical model consists of coupled ordinary differential eq...
2023-07-05 | MODEL2307050001 | BioModels
UnknownDevelopment of a Clinical Prediction Model for Anastomotic Leakage in Colorectal Surgery.
Not available
S-EPMC12538359 | biostudies-literature
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