Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse LckCre, CD4Cre-Ctnnbex3 mutants before and after T-cell transformation reveals stabilization of b-catenin induces lymphomas
Activation of b-catenin has been causatively linked to the etiology of colon cancer. Conditional stabilization of this molecule in pro-T-cells promotes thymocyte development without the requirement for preTCR signaling. We show here that activated b-catenin stalls the developmental transition from t...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7050 | biostudies-arrayexpress
TranscriptomicsGene expression profile of mouse breast cancer V720 cells treated with vehicle or PD 0332991
D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains which allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D associated...
ORGANISM(S): Mus musculus 
2012-10-16 | E-GEOD-40513 | biostudies-arrayexpress
TranscriptomicsGene expression profile of human T-ALL cell line KOPTK1 treated with vehicle or PD 0332991
D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains which allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D associated...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-40512 | biostudies-arrayexpress
Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
UnknownPhenotypic characterization and whole genome analysis of extended-spectrum beta-lactamase-producing bacteria isolated from dogs in Germany.
Not available
S-EPMC6203360 | biostudies-literature
TranscriptomicsThe Requirement for Cyclin D Function in Tumor Maintenance
This SuperSeries is composed of the following subset Series: GSE40512: Gene expression profile of human T-ALL cell line KOPTK1 treated with vehicle or PD 0332991 GSE40513: Gene expression profile of mouse breast cancer V720 cells treated with vehicle or PD 0332991 Refer to individual Series
ORGANISM(S): Mus musculus 
2012-10-16 | E-GEOD-40514 | biostudies-arrayexpress
UnknownA phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer.
Not available
S-EPMC11028316 | biostudies-literature
UnknownQuintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations.
Not available
S-EPMC5972517 | biostudies-literature
UnknownAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC7884931 | biostudies-literature
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
Sort   by:  
 Page size