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TranscriptomicsTranscriptional Profiling of isolated mouse heart cardiomyocytes and non-cardiomyocytes
Profiling of transcripts specific for cardiomyocytes and non-cardiomyocytes in the mouse heart. Cells were isolated according to: MiRNA-1/133a Clusters Regulate Adrenergic Control of Cardiac Repolarization. Besser J, Malan D, Wystub K, Bachmann A, Wietelmann A, Sasse P, Fleischmann BK, Braun T*, Bo...
ORGANISM(S): Mus musculus 
2025-07-23 | E-MTAB-15342 | biostudies-arrayexpress
Transcriptomicsmyocardial infarction in Reg3beta knock-out mice
Affymetrix microarray analysis of molecular changes after myocardial infarction. Samples of heart tissue were analyzed after myocardial infarction from WT and reg3beta knock-out mice. Samples from scar tissue and samples adjacent to the scar were analyzed. In the experiment we primarily compared inf...
ORGANISM(S): Mus musculus 
2015-06-29 | E-MTAB-2561 | biostudies-arrayexpress
TranscriptomicsNIH3T3 transfected with myocardin
NIH3T3 cell transiently transfected with myocardin-EGFP or EGFP. Transfection: Lipofectamine 2000 according to the manufacturers instructions (Invitrogen).
ORGANISM(S): Mus musculus 
2013-11-15 | E-MEXP-3869 | biostudies-arrayexpress
TranscriptomicsAnalysis of miR-1_133a function
Effect of the loss of both miR-1/133a clusters on the embryonic heart. Please note: dKO means it is a double KO of the two miR-1/133a clusters in the mouse. Control means we do not use just WT but also some heterozygous animals to compare to dKOs, however these controls do not have a phenotype. Tran...
ORGANISM(S): Mus musculus 
2013-11-15 | E-MEXP-3873 | biostudies-arrayexpress
TranscriptomicsmiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization
Analysis of the function of miR-1/133a clusters in Physiology of the adult heart. Analysis of transcriptome was perfromed for heart tissue isolated from WT (n=7), miR-1-1/133a KO (mouse chromosome 2; n=4) and miR-1-2/133a-1 KO (mouse chromosome 18; n=5) animals.
ORGANISM(S): Mus musculus 
2014-11-24 | E-MTAB-2727 | biostudies-arrayexpress
TranscriptomicsAdult cardiomyocyte specific loss of myostatin
Inhibition of myostatin signaling induces strong skeletal muscle growth making it an attractive target to treat muscle wasting and sarcopenia. However, the biological function of myostatin in the heart is barely understood. We demonstrate that conditional inactivation of myostatin in the adult murin...
ORGANISM(S): Mus musculus 
2014-05-16 | E-MEXP-3744 | biostudies-arrayexpress
Transcriptomicsneonatal rat cardiomyocytes stimulated by Oncostatin M
Molecular analysis of transcriptional changes in cardiomyocytes induced by Oncostatin M treatment. The rationale of this experiment is described in [Kubin, T., et al. Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling. Cell stem cell 9, 420-432 (2011)]
ORGANISM(S): Rattus norvegicus 
2015-02-27 | E-MTAB-2560 | biostudies-arrayexpress
Transcriptomicsc-MYC target genes in HUVEC
siRNA mediated knock-down of c-MYC vs. scrambled control in human umbilical vein endothelial cells (HUVEC).
ORGANISM(S): Homo sapiens 
2016-01-11 | E-MTAB-4025 | biostudies-arrayexpress
TranscriptomicsFOXO1 target genes in HUVEC
Adenoviral expression of a constitutive active FOXO1 vs. control GFP in human umbilical vein endothelial cells (HUVEC). Expression analysis 16 h after transduction.
ORGANISM(S): Homo sapiens 
2016-01-11 | E-MTAB-4023 | biostudies-arrayexpress
TranscriptomicsRASSF1A promotes its tumor-suppressive function via YAP1 target genes
The aim of the study was to determine the effect of the tumour suppressor RASSF1A in a stably induced YAP system, as both are members of the growth regulatory HIPPO pathway. YAP1 expression was induced by Doxycycline in stably transfected HEK293 cells. In addition the cells were transfected with RAS...
ORGANISM(S): Homo sapiens 
2017-05-15 | E-MTAB-4781 | biostudies-arrayexpress
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