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TranscriptomicsInflammation driven by tumor-specific Th1 cells protects against B-cell cancer
The immune system can both promote and suppress cancer. Chronic inflammation and proinflammatory cytokines such as interleukin (IL)-1 and IL-6 are considered tumor-promoting. In contrast, the exact nature of protective antitumor immunity remains obscure. In this study, we have quantified locally sec...
ORGANISM(S): Mus musculus 
2011-03-15 | E-GEOD-26912 | biostudies-arrayexpress
TranscriptomicsChronic lymphocytic leukemia cells are activated and proliferate in response to specific Th cells
Changes in gene expression profile of CLL cells in response to an antigen-specific Th cell clone that is specific for a Ckappa peptide of mouse Abs. Mouse anti human BCR mAbs were used to ligate BCR and deliver antigen to CLL cells. 32-45 x10e6 PBMC were incubated overnight with or without 2 μg/ml o...
ORGANISM(S): Homo sapiens 
2013-08-08 | E-GEOD-48268 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of tumor-specific Th1 cells activated in vivo
Expression data from mouse tumor-specific CD4+ T cells The central role of tumor-specific Th1 cells in fighting cancer is becoming increasingly appreciated. However, little is known about how these cells are generated in vivo. Here, we used flow cytometry and gene expression microarrays to character...
ORGANISM(S): Mus musculus 
2013-05-15 | E-GEOD-46453 | biostudies-arrayexpress
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