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GenomicsSetdb1 is required for persistence of H3K9me3 and repression of endogenous retroviruses in mouse primordial germ cells
Transcription of endogenous retroviruses (ERVs) is inhibited by de novo DNA methylation during gametogenesis, a process initiated after birth in oocytes and at ~E15.5 in prospermatogonia. Earlier in germline development however, the genome, including most retrotransposons, is progressively demethyla...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-60377 | biostudies-arrayexpress
GenomicsMaternal DNA methylation regulates early trophoblast development
Critical roles for DNA methylation in embryonic development are well established, but less is known about the roles of DNA methylation during trophoblast development, the extraembryonic lineage that gives rise to the placenta. Here we dissected the role of DNA methylation in trophoblast development ...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-66049 | biostudies-arrayexpress
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