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TranscriptomicsHDAC Inhibitors induce tumor cell-selective pro-apoptotic transcriptional responses.
The identification of recurrent somatic mutations in genes encoding epigenetic enzymes, coupled with biochemical studies demonstrating aberrant recruitment of epigenetic enzymes such as histone deacetylases (HDACs) and histone methyltransferases (HMTs) to promoter regions through association with on...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-43010 | biostudies-arrayexpress
GenomicsThe BTB-zinc finger transcription factor Abrupt acts as an epithelial oncogene in Drosophila through maintaining a progenitor-like cell state
The capacity of tumor cells to maintain continual overgrowth potential has been linked to the commandeering of normal self-renewal pathways. Using an epithelial cancer model in Drosophila we carried out an overexpression screen for oncogenes capable of cooperating with the loss of the epithelial api...
ORGANISM(S): Drosophila melanogaster 
2013-08-15 | E-GEOD-42928 | biostudies-arrayexpress
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