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MetabolomicsDissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent feature of the disease, but how it impacts on other metabolic pathways is unknown. Here, we present an analysis of mouse Pkd1 mutant ce...
2019-06-07 | MTBLS677 | MetaboLights
UnknownInhibition of Asparagine Synthetase Effectively Retards Polycystic Kidney Disease Progression
Not available
S-SCDT-10_1038-S44321-024-00071-9 | biostudies-other
MetabolomicsIntracellular iron overload rewires HSC metabolism by impairing mitochondrial fitness
Iron is an essential element for several cellular processes and recent evidence highlighted its role in regulating the function of hematopoietic stem cells (HSCs). When in excess it reduces quiescence and self-renewal, however, whether and how iron influences HSC metabolism is still unknown. Here, w...
2024-12-04 | MTBLS11778 | MetaboLights
UnknownKDM6A Loss Enhances Oxidative Phosphorylation Uncovering Tissue-Level Convergent Evolution
Not available
S-SCDT-10_1038-S44318-026-00891-0 | biostudies-other
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