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TranscriptomicsAll trans-retinoic acid (ATRA) effect on triple negative (TNBC) and luminal (LumA/LumB) primary breast tumors
We performed whole genome gene expression microarrays on short-term cultures of mammary tumors deriving from diagnostic Tru-cut procedures of 16 patients in order to evaluate transcriptional response to the retinoid. Tissue slices were challenged with vehicle (DMSO) or ATRA 0.1åµm for 48 hours. The ...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-MTAB-3313 | biostudies-arrayexpress
TranscriptomicsModulation of EDA2R/EDA-A2 signalling in Human Myoblasts
Transfection of human myoblasts was performed using Lipofectamine or electroporation. Skeletal muscle myoblasts isolated from a human male donor were transfected using the Lipofectamine™ 2000 Transfection Reagent (Invitrogen, 11668019). Twenty-four hours before transfections, cells were plated to a ...
ORGANISM(S): Homo sapiens 
2024-09-13 | E-MTAB-14239 | biostudies-arrayexpress
TranscriptomicsC2C12 Murine Myoblasts over-expressing Eda2r
C2C12 (ATCC, #CRL-1772), a myoblast cell line from the C3H mouse strain, was grown in DMEM (Dulbecco’s Modified Eagle’s Medium, Gibco), supplemented with 10% fetal bovine serum (FBS) (Euroclone, Pero, Italy) and 2 mM L-glutamine (Gibco), and maintained in culture at 37 °C with 5% CO₂, without reachi...
ORGANISM(S): Mus musculus 
2023-09-01 | E-MTAB-13101 | biostudies-arrayexpress
TranscriptomicsAll-trans retinoic reduces the levels of cardiolipins in the NB4 acute promyelocytic leukemia cell-line affecting the autophagy and differentiation responses
All-trans retinoic (ATRA) is used in the treatment of acute promyelocytic leukemia a rare form of AML characterized by the presence of a specific translocation involving chrosomes 15;17 and causing the production of the PML-RARα fusion protein in 95% of the cases. ATRA differentiates the APL blasts...
ORGANISM(S): Homo sapiens 
2022-01-31 | E-MTAB-10267 | biostudies-arrayexpress
TranscriptomicsSensitivity of gastric cancer cells to all-trans retinoic acid, a new agent in the personalized treatment of this heterogeneous tumor: definition of a predictive gene-expression model that may be used for the selection of patients who may benefit from retinoid-based treatments
All-trans retinoic acid (ATRA) is used in the treatment of Acute Promyelocytic Leukemia (APL) with exceptional results, inducing long-lasting remissions in 78% of the patients. In previous studies (Bolis M et al., Ann Oncol. 2017, 28:611; Centritto F et al., EMBO Mol Med. 2015, 7:950) we demonstrate...
ORGANISM(S): Homo sapiens 
2023-06-14 | E-MTAB-12385 | biostudies-arrayexpress
TranscriptomicsSensitivity of gastric cancer cells to all-trans retinoic acid, a new agent in the personalized treatment of this heterogeneous tumor: definition of a predictive gene-expression model that may be used for the selection of patients who may benefit from retinoid-based treatments (Xenografts)
All-trans retinoic acid (ATRA) is used in the treatment of Acute Promyelocytic Leukemia (APL) with exceptional results, inducing long-lasting remissions in 78% of the patients. In previous studies (Bolis M et al., Ann Oncol. 2017, 28:611; Centritto F et al., EMBO Mol Med. 2015, 7:950) we demonstrate...
ORGANISM(S): Homo sapiens 
2023-06-14 | E-MTAB-12394 | biostudies-arrayexpress
TranscriptomicsSensitivity of gastric cancer cells to all-trans retinoic acid, a new agent in the personalized treatment of this heterogeneous tumor: definition of a predictive gene-expression model that may be used for the selection of patients who may benefit from retinoid-based treatments (Cell Lines)
All-trans retinoic acid (ATRA) is used in the treatment of Acute Promyelocytic Leukemia (APL) with exceptional results, inducing long-lasting remissions in 78% of the patients. In previous studies (Bolis M et al., Ann Oncol. 2017, 28:611; Centritto F et al., EMBO Mol Med. 2015, 7:950) we demonstrate...
ORGANISM(S): Homo sapiens 
2023-06-15 | E-MTAB-12387 | biostudies-arrayexpress
TranscriptomicsAll trans-retinoic acid (ATRA) effect on triple negative (TNBC), HER2 positive, and luminal primary breast tumors
We performed whole genome gene expression microarrays on short-term cultures of mammary tumors deriving from diagnostic Tru-cut procedures of patients to evaluate transcriptional response to the retinoid. Tissue slices were challenged with vehicle (DMSO) or ATRA 0.1µm for 48 hours. Included are 1 l...
ORGANISM(S): Homo sapiens 
2016-10-01 | E-MTAB-4983 | biostudies-arrayexpress
TranscriptomicsAldehyde oxidase 4 (Aox4) knockout effect on Harderian Gland (HG), White Adipose Tissue(WADT) and Liver (LIV)
The mouse aldehyde oxidase, Aox4 (aldehyde oxidase 4), is a molybdo-flavoenzyme. Harderian glands are the richest source of Aox4, although the protein is detectable also in sebaceous glands, epidermis and other keratinized epithelia. We performed whole genome gene expression experiment on Harderian ...
ORGANISM(S): Mus musculus 
2015-09-15 | E-MTAB-3820 | biostudies-arrayexpress
TranscriptomicsGene-expression profiling of SEPN1 knockout or wild type mice injected with either ERO1 or PBS
Endoplasmic reticulum (ER) and oxidative stress are two related phenomena that have important metabolic consequences. As many skeletal muscle diseases are triggered by oxidative stress, we explored the chain of events linking a hyper oxidized ER (which causes ER and oxidative stress) with skeletal m...
ORGANISM(S): Mus musculus 
2016-10-01 | E-MTAB-4933 | biostudies-arrayexpress
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