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TranscriptomicsOncogene activation induces metabolic transformation resulting in insulin independence in human breast cancer cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-03-18 | E-GEOD-23176 | biostudies-arrayexpress
UnknownPancreatic cancer stem-like cells display aggressive behavior mediated via activation of FoxQ1
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-51971 | biostudies-other
UnknownGenome-wide analysis of time-dependent gene expression in SUM-225 cells treated with the HER-2-specific inhibitor CP724,714 for 45 hours
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-22955 | biostudies-other
TranscriptomicsHER-2 signaling, acquisition of growth factor independence, and regulation of biological networks associated with cell transformation
This SuperSeries is composed of the following subset Series: GSE23135: Genome-wide analysis of time-dependent gene expression in MCF-10A cells treated with the EGFR-specific inhibitor gefitinib for 45 hours GSE23136: Genome-wide analysis of time-dependent gene expression in MCF-10HER-2 cells treated...
ORGANISM(S): Homo sapiens 
2010-08-24 | E-GEOD-23175 | biostudies-arrayexpress
TranscriptomicsNetwork Understanding of SNAIL inhibitor induced perturbations in EMT models
Two engineered HMLE cell lines representing various degrees of EMT were treated with a drug in development to target and inhibit SNAIL interaction with PTP53, called GN-25 total RNA was isolated and analyzed in an Agilent two-color experiment. Four biological replicates of each condition were direct...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-44397 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression changes in KPT330-treated HMLE cells transduced to stably overexpress SNAI1
HMLE-SNAIL cell cultures were treated with KPT330 drug (KPT, 150 nanomolar) or vehicle (DMSO) for 24 hours, in parallel quadruplicates. KPT-330 is an Exportin 1 (XPO1) inhibitor with possible pluripotent or unexpected effects on cell signaling. Total RNA was isolated and analyzed in an Agilent two-...
ORGANISM(S): Homo sapiens 
2015-08-31 | E-GEOD-69326 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of time-dependent gene expression in SUM-225 cells treated with the HER-2-specific inhibitor CP724,714 for 45 hours
Results of blocking the HER-2 oncogene kinase function in SUM-225 cells by treatment with CP724,714 and measuring gene expression as a function of time provides information as to what genes are regulated by HER-2 in this breast cancer cell line. SUM-225 cells were treated with the HER-2-specific sma...
ORGANISM(S): Homo sapiens 
2011-03-18 | E-GEOD-22955 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of time-dependent gene expression in MCF-10A cells treated with the HER-2-specific inhibitor CP724,714 for 45 hours
Results of blocking HER-2 kinase activity in MCF-10A cells by treatment with CP724,714 and measuring gene expression as a function of time provides information as to what genes are regulated by HER-2 in these nontransformed breast epithelial cells. MCF-10A cells were treated with the HER-2-specific ...
ORGANISM(S): Homo sapiens 
2011-03-18 | E-GEOD-23138 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of time-dependent gene expression in MCF-10A cells treated with the EGFR-specific inhibitor gefitinib for 45 hours
Results of blocking EGFR kinase activity in MCF-10A cells by treatment with gefitinib and measuring gene expression as a function of time provides information as to what genes are regulated by EGFR in these nontransformed breast epithelial cells. MCF-10A cells were treated with the EGFR-specific sma...
ORGANISM(S): Homo sapiens 
2010-08-24 | E-GEOD-23135 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of time-dependent gene expression in MCF-10HER-2/E7 cells treated with the HER-2-specific inhibitor CP724,714 for 45 hours
Results of blocking the activated HER-2 oncogene kinase activity in MCF-10HER-2/E7 cells by treatment with CP724,714 and measuring gene expression as a function of time provides information as to what genes are regulated by HER-2 in these transformed breast epithelial cells. MCF-10HER-2/E7 cells wer...
ORGANISM(S): Homo sapiens 
2010-08-24 | E-GEOD-23139 | biostudies-arrayexpress
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