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TranscriptomicsSingle-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans
Gold nanoparticles (GNPs) have been used in the development of novel therapies as a way of delivery of both stimulatory and tolerogenic peptide cargoes. Here we report that intradermal injection of GNPs loaded with the proinsulin peptide C19-A3, in patients with type 1 diabetes, results in recruitme...
ORGANISM(S): Homo sapiens 
2023-10-06 | E-MTAB-13388 | biostudies-arrayexpress
TranscriptomicsBulk RNAseq of punch biopsies following intradermal injection of gold nanoparticles loaded with diabetes autoantigen, or unijected controls, in humans
the Enhanced Epidermal Antigen Specific Immunotherapy Trial -1 (EEASI) study was a two-centre, open-label, uncontrolled, single-group first-in-human Phase 1A safety study of C19-A3 GNP peptide in individuals with T1D (https://clinicaltrials.gov/ct2/show/NCT02837094). The investigational medicinal pr...
ORGANISM(S): Homo sapiens 
2023-10-06 | E-MTAB-13386 | biostudies-arrayexpress
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