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MetabolomicsFerritin aggregation: A neotype and universal engager for CAR T cell avidity engineering against diverse refractory leukemias

Introduction: Primary liver cancer remains the third leading cause of global cancer-related mortality, with hepatocellular carcinoma (HCC) constituting the predominant histological subtype. The development of malignant ascites in advanced HCC patients signifies metastatic progression and portends...

2025-12-24 | MTBLS13569 | MetaboLights
GenomicsOvercoming T cell tolerance to tumor self-antigens through catch-bond engineering
Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering
PRJNA1321921 | ENA
GenomicsOvercoming T cell tolerance to tumor self-antigens through catch-bond engineering - TCR156wt and S32M
Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering - TCR156wt and S32M
PRJNA1322290 | ENA
TranscriptomicsOvercoming T cell tolerance to tumor self-antigens through catch-bond engineering
T cells are often weakly responsive to tumor self-antigens because of central tolerance, which constrains their ability to eliminate tumors. Affinity-matured T cell receptors can exhibit enhanced tumor killing properties but in therapeutic settings have been accompanied by off-target cross-reactivit...
ORGANISM(S): Homo sapiens 
2026-03-25 | GSE307528 | GEO
OtherOvercoming T cell tolerance to tumor self-antigens through catch-bond engineering - TCR156wt and S32M
T cells are often weakly responsive to tumor self-antigens because of central tolerance, which constrains their ability to eliminate tumors. Affinity-matured T cell receptors can exhibit enhanced tumor killing properties but in therapeutic settings have been accompanied by off-target cross-reactivit...
ORGANISM(S): Saccharomyces cerevisiae 
2026-03-25 | GSE307565 | GEO
ProteomicsReduced PRC2 function causes asparaginase resistance in T-ALL by decreasing WNT pathway activity
Loss-of-function mutations and deletions in the core components of the epigenetic polycomb repressive complex 2 (PRC2) are associated with poor initial treatment response in T-cell acute lymphoblastic leukemia (T-ALL), but the mechanisms that underpin resistance to individual therapies are unknown. ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD045010 | Pride
ProteomicsGlycans on Non-Structural Protein 1 Prevent Premature T-cell Mediated Dengue Virus Clearance
Non-structural protein 1 (NS1) of dengue virus (DENV) harbours two conserved N-glycosylation sites at positions 130 and 207, whose biological roles have remained elusive. Using a clinically relevant mouse model of severe dengue, we showed that DENV that lacked N207 glycans on NS1 was significantly a...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD065422 | Pride
Dengue/glycosylation/pd-1/ns1/t-cell apoptosis. 
UnknownOne-Electron Oxidation of [M(P(t) Bu3 )2 ] (M=Pd, Pt): Isolation of Monomeric [Pd(P(t) Bu3 )2 ](+) and Redox-Promoted C-H Bond Cyclometalation.
Not available
S-EPMC4797707 | biostudies-literature
UnknownRaman spectroscopic detection of the T-Hg II-T base pair and the ionic characteristics of mercury.
Not available
S-EPMC3384328 | biostudies-literature
UnknownQuantifying rival bond fission probabilities following photoexcitation: C-S bond fission in t-butylmethylsulfide.
Not available
S-EPMC6540878 | biostudies-literature
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