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MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
ProteomicsMouse bone marrow fibrosis LC-MS/MS
Bone marrow fibrosis (BMF) disrupts normal blood cell production, and excessive activation of the TGF-β signaling pathway is considered a key factor in the progression of the disease. Therefore, regulating TGF-β secretion is crucial for reversing fibrotic conditions. Histone deacetylase inhibitors (...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD055276 | Pride
Mouse Bone marrow fibrosis Lc-ms/ms 
TranscriptomicsInhibition of Peripheral Serotonin Activates Hepatic AMPK and Reduces Monocyte-Derived Liver Macrophages, Ameliorating Obesity-Associated Fibrosis
Monocyte-derived liver macrophages are critical in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis, but their recruitment mechanisms remain unclear. Serotonin (5-hydroxytryptamine, 5HT) is a conserved monoamine synthesized by tryptophan hydroxylase (Tph...
ORGANISM(S): Mus musculus 
2025-10-30 | E-MTAB-15760 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of murine bone marrow cells
TGF-M-NM-21 signaling pathway of bone marrow of the Gata1low mouse model of myelofibrosis Four condition experiment. Biological replicates: 3 control CD1 mice, 3 Gata1low mice, 3 SB431542-treated Gata1low mice and 3 Vehicle-treated Gata1low mice.
ORGANISM(S): Mus musculus 
2013-03-02 | E-GEOD-44797 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of WT and Mmp10-/- bone marrow-derived macrophages after infection with Pseudomonas aeruginosa
Several members of the matrix metalloproteinase (MMP) family control specific immune processes, such as leukocyte influx and chemokine activity. Stromelysin-2 (MMP10) is expressed in numerous tissues after injury; however, little is known of its function. Here, we report that MMP10 is expressed by m...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-78175 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of human mononuclear cells from bone marrow.
Activation of non-canonical TGF-β1 signaling indicates an autoimmune mechanism for bone marrow fibrosis in primary myelofibrosis Two condition experiment. Biological replicates: 3 control human healty subjects, 3 PMF patients
ORGANISM(S): Homo sapiens 
2014-09-27 | E-GEOD-61819 | biostudies-arrayexpress
GenomicsGli1+ cells in bone marrow fibrosis
Gli1+ cells as a driver and key target in bone marrow fibrosis
PRJEB19811 | ENA
GenomicsWnt-dependent spatiotemporal reprogramming of bone marrow niches drives fibrosis
Wnt-dependent spatiotemporal reprogramming of bone marrow niches drives fibrosis
PRJNA1189074 | ENA
TranscriptomicsTranscriptome analysis of bone marrow mesenchymal stromal cells from patients with Primary Myelofibrosis
Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm whose severity and treatment complexity is attributed to the presence of bone marrow (BM) fibrosis and alterations of stroma impairing the production of normal blood cells. Despite the recently discovered mutations including the JA...
ORGANISM(S): Homo sapiens 
2015-01-10 | E-GEOD-44426 | biostudies-arrayexpress
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